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ID 49712
本文ファイル
著者
Minamizaki, Tomoko 大学院医歯薬保健学研究院 広大研究者総覧
Yoshiko, Yuji 大学院医歯薬保健学研究院 広大研究者総覧
キーワード
Acidic serine- and aspartic acid-rich motif (ASARM)
bone mineralization
matrix extracellular phosphoglycoprotein (MEPE)
small integrin-binding ligand N-linked glycoprotein (SIBLING)
抄録(英)
The organic component of the bone matrix comprises 40% dry weight of bone. The organic component is mostly composed of type I collagen and small amounts of non-collagenous proteins (NCPs) (10-15% of the total bone protein content). The small integrin-binding ligand N-linked glycoprotein (SIBLING) family, a NCP, is considered to play a key role in bone mineralization. SIBLING family of proteins share common structural features and includes the arginine-glycine-aspartic acid (RGD) motif and acidic serine- and aspartic acid-rich motif (ASARM). Clinical manifestations of gene mutations and/or genetically modified mice indicate that SIBLINGs play diverse roles in bone and extraskeletal tissues. ASARM peptides might not be primary responsible for the functional diversity of SIBLINGs, but this motif is suggested to be a key domain of SIBLINGs. However, the exact function of ASARM peptides is poorly understood. In this article, we discuss the considerable progress made in understanding the role of ASARM as a bioactive peptide.
掲載誌名
Current Protein & Peptide Science
16巻
3号
開始ページ
196
終了ページ
202
出版年月日
2015
出版者
Bentham Science Publishers
ISSN
1389-2037
1875-5550
出版者DOI
PubMedID
言語
英語
NII資源タイプ
学術雑誌論文
広大資料タイプ
学術雑誌論文
DCMIタイプ
text
フォーマット
application/pdf
著者版フラグ
author
権利情報
The published manuscript is available at EurekaSelect via http://www.eurekaselect.com/openurl/content.php?genre=article&doi=10.2174/1389203716666150206122839.
This is not the published version. Please cite only the published version. この論文は出版社版ではありません。引用の際には出版社版をご確認、ご利用ください。
関連情報URL
部局名
医歯薬保健学研究科