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ID 48984
本文ファイル
著者
Yamamoto, Ryoko
Minamizaki, Tomoko 大学院医歯薬保健学研究院 広大研究者総覧
Yoshiko, Yuji 大学院医歯薬保健学研究院 広大研究者総覧
Yoshioka, Hirotaka 大学院医歯薬保健学研究院(歯)
Tanne, Kazuo
Aubin, Jane E
Maeda, Norihiko
抄録(英)
Osteoblasts/osteocytes are the principle sources of fibroblast growth factor 23 (FGF23), a phosphaturic hormone, but the regulation of FGF23 expression during osteoblast development remains uncertain. Because 1α,25-dihydroxyvitamin D3 (1,25(OH)2D3) and inorganic phosphate (Pi) may act as potent activators of FGF23 expression, we estimated how these molecules regulate FGF23 expression during rat osteoblast development in vitro. 1,25(OH)2D3-dependent FGF23 production was restricted largely to mature cells in correlation with increased vitamin D receptor (VDR) mRNA levels, in particular, when Pi was present. Pi alone and more so in combination with 1,25(OH)2D3 increased FGF23 production and VDR mRNA expression. Parathyroid hormone, stanniocalcin 1, prostaglandin E2, FGF2, and foscarnet did not increase FGF23 mRNA expression. Thus, these results suggest that 1,25(OH)2D3 may exert its largest effect on FGF23 expression/production when exposed to high levels of extracellular Pi in osteoblasts/osteocytes.
内容記述
This work was supported in part by grants from the Ministry of Education, Science, Sports and Culture of Japan (18592001 to YY) and the Canadian Institutes of Health Research (FRN 83704 to JEA).
掲載誌名
Journal of Endocrinology
206巻
3号
開始ページ
279
終了ページ
286
出版年月日
2010-09
出版者
Society for Endocrinology
ISSN
0022-0795
1479-6805
出版者DOI
PubMedID
言語
英語
NII資源タイプ
学術雑誌論文
広大資料タイプ
学術雑誌論文
DCMIタイプ
text
フォーマット
application/pdf
著者版フラグ
publisher
権利情報
© 2010 Society for Endocrinology. This is an Open Access article distributed under the terms of the Society for Endocrinology’s Re-use Licence which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
関連情報URL
部局名
医歯薬保健学研究科