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ID 48982
本文ファイル
著者
Takei, Yuichiro 大学院医歯薬保健学研究院(歯)
Minamizaki, Tomoko 大学院医歯薬保健学研究院(歯) 広大研究者総覧
Yoshiko, Yuji 大学院医歯薬保健学研究院(歯) 広大研究者総覧
抄録(英)
The functional significance of fibroblast growth factor (FGF) signaling in bone formation has been demonstrated through genetic loss-of-function and gain-of-function approaches. FGFs, comprising 22 family members, are classified into three subfamilies: canonical, hormone-like, and intracellular. The former two subfamilies activate their signaling pathways through FGF receptors (FGFRs). Currently, intracellular FGFs appear to be primarily involved in the nervous system. Canonical FGFs such as FGF2 play significant roles in bone formation, and precise spatiotemporal control of FGFs and FGFRs at the transcriptional and posttranscriptional levels may allow for the functional diversity of FGFs during bone formation. Recently, several research groups, including ours, have shown that FGF23, a member of the hormone-like FGF subfamily, is primarily expressed in osteocytes/osteoblasts.This polypeptide decreases serum phosphate levels by inhibiting renal phosphate reabsorption and vitamin D3 activation, resulting in mineralization defects in the bone. Thus, FGFs are involved in the positive and negative regulation of bone formation. In this review, we focus on the reciprocal roles of FGFs in bone formation in relation to their local versus systemic effects.
掲載誌名
International Journal of Endocrinology
2015巻
開始ページ
729352
出版年月日
2015-03-19
出版者
Hindawi Publishing Corporation
ISSN
1687-8337
1687-8345
出版者DOI
PubMedID
言語
英語
NII資源タイプ
学術雑誌論文
広大資料タイプ
学術雑誌論文
DCMIタイプ
text
フォーマット
application/pdf
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publisher
権利情報
Copyright © 2015 Yuichiro Takei et al.This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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部局名
医歯薬保健学研究科