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ID 45928
本文ファイル
著者
Kitagawa, Chiyoe
Saka, Hideo
Kada, Akiko
Saito, Akiko M.
Takei, Hidefumi
Matsutani, Noriyuki
Takahashi, Noriaki
Mineshita, Masamichi
Kawano, Osamu
Bessho, Akihiro
Miyazawa, Hideki
キーワード
secondary pneumothorax
talc
pleurodesis
NDC
医学
抄録(英)
A pneumothorax can be primary or secondary. A high proportion of patients with secondary spontaneous pneumothorax are the elderly who are in poor general condition due to their impaired cardiac and pulmonary functions as well as due to other complications. Therefore, it may be difficult for these patients to undergo surgical procedures; in addition, the elderly may be at high risk for postoperative pulmonary fistula due to severe adhesions and emphysema complications. These non-operative and high-risk cases may be treated with pleurodesis (a procedure that involves instillation of a chemical or irritant into the thoracic cavity through an injection), bronchoscopic bronchial embolisation, or other procedures. In Japan, no device is currently approved for performing pleurodesis, but an approval of one device is expected soon. This will be an open-label, single-arm multicentre study conducted among 30 patients with secondary intractable pneumothorax who are not indicated to undergo surgery. The primary endpoint will be presence or absence of chest tube removal. The secondary endpoints will be the disappearance/decrease of air leakage, grade of dyspnoea, and duration of drainage. This study will assess the safety and efficacy of sterile graded talc pleurodesis in patients with secondary intractable pneumothorax.
内容記述
This research is (partially) supported by the Project Promoting Clinical Trials for Development of New Drugs and Medical Devices (Japan Medical Association) and Early/Exploratory Clinical Trial Center Development Projects from the Japan Agency for Medical Research and Development (AMED).
This study is registered in the Center for Clinical Trials, Japan Medical Association (JMA-IIA00272).
掲載誌名
Hiroshima Journal of Medical Sciences
67巻
1号
開始ページ
15
終了ページ
20
出版年月日
2018-03
出版者
Hiroshima University Medical Press
ISSN
0018-2052
2433-7668
NCID
出版者DOI
言語
英語
NII資源タイプ
紀要論文
広大資料タイプ
学内刊行物(紀要等)
DCMIタイプ
text
フォーマット
application/pdf
著者版フラグ
publisher
権利情報
Copyright (c) 2018 Hiroshima University Medical Press
関連情報URL
部局名
医歯薬保健学研究科
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