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ID 48709
本文ファイル
著者
Sakuma, Chisako
Okmura, Misako
Umehara, Tomoki
Miura, Masayuki
Chihara, Takahiro 大学院理学研究科 広大研究者総覧
抄録(英)
During neural development, regulation of microtubule stability is essential for proper morphogenesis of neurons. Recently, the striatin-interacting phosphatase and kinase (STRIPAK) complex was revealed to be involved in diverse cellular processes. However, there is little evidence that STRIPAK components regulate microtubule dynamics, especially in vivo. Here, we show that one of the core STRIPAK components, Strip, is required for microtubule organization during neuronal morphogenesis. Knockdown of Strip causes a decrease in the level of acetylated α-tubulin in Drosophila S2 cells, suggesting that Strip influences the stability of microtubules. We also found that Strip physically and genetically interacts with tubulin folding cofactor D (TBCD), an essential regulator of α- and β-tubulin heterodimers. Furthermore, we demonstrate the genetic interaction between strip and Down syndrome cell adhesion molecule (Dscam), a cell surface molecule that is known to work with TBCD. Thus, we propose that Strip regulates neuronal morphogenesis by affecting microtubule stability.
内容記述
This work was supported by grants from the Japanese Ministry of Education, Science, Sports, Culture and Technology (MEXT), the Japan Society for the Promotion of Science and the Japan Science and Technology Agency (to C.S., M.O., M.M. and T.C.).
掲載誌名
Scientific Reports
5巻
開始ページ
17769
出版年月日
2015-12-08
出版者
Nature Research
ISSN
2045-2322
出版者DOI
PubMedID
言語
英語
NII資源タイプ
学術雑誌論文
広大資料タイプ
学術雑誌論文
DCMIタイプ
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This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
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部局名
理学研究科