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ID 48683
本文ファイル
著者
Tsuji, Mayumi
Shibata, Eiji
Askew, David J.
Morokuma, Seiichi
Aiko, Yukiyo
Senju, Ayako
Araki, Shunsuke
Sanefuji, Masafumi
Ishihara, Yasuhiro 大学院総合科学研究科 広大研究者総覧
Tanaka, Rie
Kusuhara, Koichi
Kawamoto, Toshihiro
Japan Environment and Children’s Study Group
キーワード
Metal concentration
Placenta previa
Placenta accreta
Pregnancy
抄録(英)
Background: Placenta previa and placenta accreta associate with high morbidity and mortality for both mothers and fetus. Metal exposure may have relationships with placenta previa and placenta accreta. This study analyzed the associations between maternal metal (cadmium [Cd], lead [Pb], mercury [Hg], selenium [Se], and manganese [Mn]) concentrations and placenta previa and placenta accreta.
Methods: We recruited 17,414 women with singleton pregnancies. Data from a self-administered questionnaire regarding the first trimester and medical records after delivery were analyzed. Maternal blood samples were collected to measure metal concentrations. The subjects were classified into four quartiles (Q1, Q2, Q3, and Q4) according to metal concentrations.
Results: The odds ratio for placenta previa was significantly higher among subjects with Q4 Cd than those with Q1 Cd. The odds ratio for placenta previa was significantly higher for subjects with Q2 Pb than those with Q1 Pb.
Conclusion: Participants with placenta previa had higher Cd concentrations. However, this study was crosssectional and lacked important information related to Cd concentration, such as detailed smoking habits and sources of Cd intake. In addition, the subjects in this study comprised ordinary pregnant Japanese women, and it was impossible to observe the relationship between a wide range of Cd exposure and placenta previa. Therefore, epidemiological and experimental studies are warranted to verify the relationship between Cd exposure and pregnancy abnormalities.
内容記述
This study was funded and supported by the Ministry of the Environment of Japan. The findings and conclusions of this article are solely the responsibility of the authors and do not represent the official views of this government agency.
掲載誌名
Environmental Health and Preventive Medicine
24巻
1号
開始ページ
40
出版年月日
2019-06-07
出版者
BMC
ISSN
1342-078X
1347-4715
出版者DOI
PubMedID
言語
英語
NII資源タイプ
学術雑誌論文
広大資料タイプ
学術雑誌論文
DCMIタイプ
text
フォーマット
application/pdf
著者版フラグ
publisher
権利情報
© The Author(s). 2019 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
関連情報URL
部局名
総合科学研究科
統合生命科学研究科