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ID 37798
本文ファイル
著者
Fujii, Satoshi
Kaneko, Mayumi
Inai, Kouki
キーワード
Replication error (RER)
Loss of heterozygosity (LOH)
Young
Bilateral breast cancer
NDC
医学
抄録(英)
We examined breast cancers from 67 female patients to ascertain the possible correlation between RER or LOH status, age and bilaterality using eight microsatellite markers on chromosomes 2p, 3p, 16q, 17p and 17q. The frequencies of RER in young patients (25-35 years old), patients with double primary disease (43-77 years old) and patients with contralateral metastases (46-72 years old) were 35%, 63%, and 80%, respectively, while that in elderly patients (60-81 years old) was 0%. In contrast, there were no statistically significant differences in the frequency of LOH between these groups. Our results suggest that RER might play an important role in the occurrence of breast cancer at a younger age and in bilateral breast cancer.
掲載誌名
Hiroshima Journal of Medical Sciences
47巻
3号
開始ページ
89
終了ページ
97
出版年月日
1998-09
出版者
Hiroshima University Medical Press
ISSN
0018-2052
NCID
言語
英語
NII資源タイプ
紀要論文
広大資料タイプ
学内刊行物(紀要等)
DCMIタイプ
text
フォーマット
application/pdf
著者版フラグ
publisher
部局名
医歯薬学総合研究科
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