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ID 25933
本文ファイル
著者
Uemura, Kenichiro
Hayashidani, Yasuo
Shimamoto, Fumio
キーワード
ampullary carcinoma
prognostic factor
perineural invasion
pancreatoduodenectomy
NDC
医学
抄録(英)
Purpose: The aim of this study was to identify prognostic factors in patients undergoing pancreatoduodenectomy with lymphadenectomy for ampullary carcinoma.

Methods: The records of 46 consecutive patients with ampullary carcinoma who underwent pancreatoduodenectomy from 1988 through 2006 were retrospectively reviewed.

Results: A 98% rate of potentially curative (R0) resection was achieved. There was no 30-day mortality. Overall 5-year survival rate was 64%.0 Univariate analysis revealed that T3 and T4 tumor (ie, pancreatic parenchymal invasion) (P<0.001), lymph node metastasis (P=0.01), and perineural invasion (P<0.001) were significant predictors of poor prognosis. Furthermore, perineural invasion was found to be a significant independent predictor of poor prognosis by multivariate analysis (P=0.024).

Conclusions: Pancreatoduodenectomy with lymphadenectomy for ampullary carcinoma is a safe surgical procedure with an acceptable cure rate. The presence of perineural invasion may be useful for predicting poor prognosis in patients with ampullary carcinoma who undergo potentially curative resection.
掲載誌名
Digestive Diseases and Sciences
53巻
8号
開始ページ
2281
終了ページ
2286
出版年月日
2008-08
出版者
Springer Netherlands
ISSN
0163-2116
NCID
出版者DOI
言語
英語
NII資源タイプ
学術雑誌論文
広大資料タイプ
学術雑誌論文
DCMIタイプ
text
フォーマット
application/pdf
著者版フラグ
author
権利情報
Copyright (c) 2008 Springer
関連情報
The original publication is available at www.springerlink.com
関連情報URL
部局名
医歯薬学総合研究科