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ID 17221
本文ファイル
著者
Ogata, Toru
Gregoire, Lucie
Goddard, Katrina AB
Skunca, Magdalena
Tromp, Gerard
Lancaster, Wayne D
Parrado, Antonio R
Lu, Qing
Shibamura, Hidenori
Sakalihasan, Natzi
Limet, Raymond
MacKean, Gerald L
Arthur, Claudette
Kuivaniemi, Helena
NDC
医学
抄録(英)
Background: Chronic inflammation and autoimmunity likely contribute to the pathogenesis of abdominal aortic aneurysms (AAAs). The aim of this study was to investigate the role of autoimmunity in the etiology of AAAs using a genetic association study approach with HLA polymorphisms. Methods: HLA-DQA1, -DQB1, -DRB1 and -DRB3-5 alleles were determined in 387 AAA cases (180 Belgian and 207 Canadian) and 426 controls (269 Belgian and 157 Canadian) by a PCR and single-strand oligonucleotide probe hybridization assay. Results: We observed a potential association with the HLA-DQA1 locus among Belgian males (empirical p = 0.027, asymptotic p = 0.071). Specifically, there was a significant difference in the HLA-DQA1*0102 allele frequencies between AAA cases (67/322 alleles, 20.8%) and controls (44/356 alleles, 12.4%) in Belgian males (empirical p = 0.019, asymptotic p = 0.003). In haplotype analyses, marginally significant association was found between AAA and haplotype HLA-DQA1-DRB1 (p = 0.049 with global score statistics and p = 0.002 with haplotype-specific score statistics). Conclusion: This study showed potential evidence that the HLA-DQA1 locus harbors a genetic risk factor for AAAs suggesting that autoimmunity plays a role in the pathogenesis of AAAs.
掲載誌名
BMC Medical Genetics
7巻
開始ページ
67
出版年月日
2006-07-31
出版者
BioMed Central
ISSN
1471-2350
NCID
出版者DOI
PubMedID
言語
英語
NII資源タイプ
学術雑誌論文
広大資料タイプ
学術雑誌論文
DCMIタイプ
text
フォーマット
application/pdf
著者版フラグ
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権利情報
Copyright (c) 2006 Ogata et al; licensee BioMed Central Ltd.
関連情報URL
部局名
医歯薬学総合研究科