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ID 25913
本文ファイル
著者
Hosoi, Toru 大学院医歯薬保健学研究院(薬)
Saito, Atsushi 大学院医歯薬保健学研究院(医) 広大研究者総覧
Kume, Ayaka
Okuma, Yasunobu
Nomura, Yasuyuki
Ozawa, Koichiro 大学院医歯薬保健学研究院(薬) 広大研究者総覧
キーワード
endoplasmic reticulum stress
vanadate; glucose-regulated protein 78 (GRP78)
CCAAT/enhancer-binding protein homologous protein (CHOP)
NDC
医学
抄録(英)
The disruption of endoplasmic reticulum function leads to an accumulation of unfolded proteins, which results in endoplasmic reticulum stress. In the present study, we investigated the effect of vanadate on such stress. Endoplasmic reticulum stress increased glucose-regulated protein 78 (GRP78) and CCAAT/enhancer-binding protein homologous protein (CHOP) expressions in glial cell cultures. We found that vanadate inhibited the endoplasmic reticulum stress-induced increase in GRP78 and CHOP expressions at both mRNA and protein levels. Thus, these results suggest that vanadate modulates endoplasmic reticulum stress responses and that novel vanadate-responsive protein(s) might be involved in these processes.
掲載誌名
European Journal of Pharmacology
594巻
1-3号
開始ページ
44
終了ページ
48
出版年月日
2008-10-10
出版者
Elsevier Science BV
ISSN
0014-2999
NCID
出版者DOI
言語
英語
NII資源タイプ
学術雑誌論文
広大資料タイプ
学術雑誌論文
DCMIタイプ
text
フォーマット
application/pdf
著者版フラグ
author
権利情報
Crown Copyright (c) 2008 Published by Elsevier B.V. All rights reserved.
関連情報URL
部局名
医歯薬学総合研究科