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ID 20793
本文ファイル
著者
Matsuura, Natsue
Ozawa, Junya
Kai, Satoru
Sakakima, Harutoshi
Abiko, Sachiko
NDC
医学
抄録(英)
To study injury and subsequent changes in skeletal muscles, the rat sciatic nerve was electrically stimulated at 50 Hz and muscle contraction was induced for 30 min. Muscle damage was classified into five types (hypercontraction, hyperstretching, Z band disorders, misalignment of myofilament and regions of scarce myofilaments) by electron microscopy and quantified by ultrastructural assessment. After electrical nerve stimulation, the percentages of the injured areas of the soleus muscle were 18.8 ± 15.8% (mean ± SD) at O h, 9.7 ± 1.0 0x1.3f1c4p-890t 6 h, 22.0 ± 23.6 0x0p+0t 12 h, 13.1 ± 3.2 0x0p+0t 24 h, 4.9 ± 6.0 0x0p+0t 3 days and 0.5 ± 0.4 0x0p+0t 7 days. At 0 h, the vast majority of ultrastructural alterations were sarcomere hypercontraction. At 6 h, hypercontraction was not recognizable and sarcomere hyperstretching and Z band disarrangement constituted the major findings. At 12 h, when the injury reaehed its maximum, myofilament disorganization and hyperstretching were predominant. At 24 h or afterwards, the injury began to decrease and recovered to almost normal conditions by 7 days. There were very few necrotic muscle fibers in all specimens. It is considered that the muscle lesions in the present study were reversible, and recovered through changes in various types of sarcomere alterations. Z band streaming and free ribosomes were frequently found at 12 and 24 h, which may indicate repair processes rather than newly formed lesions.
掲載誌名
Archives of Histology and Cytology
64巻
4号
開始ページ
393
終了ページ
400
出版年月日
2001
出版者
International Society of Histology and Cytology
ISSN
0914-9465
NCID
出版者DOI
PubMedID
言語
英語
NII資源タイプ
学術雑誌論文
広大資料タイプ
学術雑誌論文
DCMIタイプ
text
フォーマット
application/pdf
著者版フラグ
publisher
関連情報URL
部局名
保健学研究科