このエントリーをはてなブックマークに追加
ID 28528
本文ファイル
別タイトル
ラット脊髄の圧迫後における神経細胞損失の経過と範囲
著者
Takemoto, Hidenori
Yoshimura, Osamu
Moriyama, Hideki
Imagita, Hidetaka
Shirahama, Kunji
Kajihara, Hiroki
Tobimatsu, Yoshiko
キーワード
neuronal loss
spinal cord compression
rat
NDC
医学
抄録(英)
Motor deficits after spinal cord injury arise from damages to the descending spinal pathways and ventral motoneurons (VMN). In contrast to data on damages to the white matter or the descending spinal pathways, few quantitative data on damages to VMN after injury are available currently. The purpose of this study was to examine quantitatively the temporal and spatial pattern of VMN loss after spinal cord compression. Two groups of adult female Wistar rats were used in this study: rats which were subjected to spinal cord compression in short duration with an aneurysm clip (experimental group) and rats which were subjected to a sham-operation (control group). Using serial cross-sections of the spinal cord, VMN were counted up to the 7th day after surgical intervention at 0, 1, 2, and 3 mm rostral and caudal to the lesion epicenter (experimental group) or to the median of the serial sections (control group). At 15 minutes after the compression, VMN were lost only at the epicenter section and no VMN were observed there. By 8 hours, VMN loss had spread to next 1 mm rostral and caudal section to the epicenter. Virtually, no further loss was detected between 8 hours and later time points. This study showed that compression to the adult rat spinal cord in short duration led to VMN loss, which progressed acutely and expanded modestly. Our findings could be used to develop effective treatment and provide a better understanding of VMN loss after spinal cord injury.
掲載誌名
広島大学保健学ジャーナル
6巻
2号
開始ページ
111
終了ページ
117
出版年月日
2007-09-28
出版者
広島大学保健学出版会
ISSN
1347-7323
NCID
SelfDOI
言語
英語
NII資源タイプ
紀要論文
広大資料タイプ
学内刊行物(紀要等)
DCMIタイプ
text
フォーマット
application/pdf
著者版フラグ
publisher
部局名
保健学研究科
他の一覧