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ID 50436
本文ファイル
著者
Kawahara, Daisuke 大学院医系科学研究科(医) 広大研究者総覧
Ozawa, Shuichi
Shiinoki, Takehiro
Kimura, Tomoki 病院(医)
Tsubouchi, Kento
Nagata, Yasushi 大学院医系科学研究科(医) 広大研究者総覧
キーワード
biological equivalent dose
dosimetric margin
LQ model
SBRT
抄録(英)
Purpose: To develop a novel biological dosimetric margin (BDM) and to create a biological conversion factor (BCF) that compensates for the difference between physical dosimetric margin (PDM) and BDM, which provides a novel scheme of a direct estimation of the BDM from the physical dose (PD) distribution.
Methods: The offset to isocenter was applied in 1‐mm steps along left‐right (LR), anterior‐posterior (AP), and cranio‐caudal (CC) directions for 10 treatment plans of lung stereotactic body radiation therapy (SBRT) with a prescribed dose of 48 Gy. These plans were recalculated to biological equivalent dose (BED) by the linearquadratic model for the dose per fraction (DPF) of d = 3–20 Gy/fr and α/β= 3 - 10. BDM and PDM were defined so that the region that satisfied that the dose covering 95% (or 98%) of the clinical target volume was greater than or equal to the 90% of the prescribed PD and BED, respectively. An empirical formula of the BCF was created as a function of the DPF.
Results: There was no significant difference between LR and AP directions for neither the PDM nor BDM. On the other hand, BDM and PDM in the CC direction were significantly larger than in the other directions. BCFs of D95% and D98% were derived for the transverse (LR and AP) and longitudinal (CC) directions.
Conclusions: A novel scheme to directly estimate the BDM using the BCF was developed. This technique is expected to enable the BED‐based SBRT treatment planning using PD‐based treatment planning systems.
掲載誌名
Journal of Applied Clinical Medical Physics
21巻
4号
開始ページ
31
終了ページ
41
出版年月日
2020-04-20
出版者
American Association of Physicists in Medicine
Wiley
ISSN
1526-9914
出版者DOI
PubMedID
言語
英語
NII資源タイプ
学術雑誌論文
広大資料タイプ
学術雑誌論文
DCMIタイプ
text
フォーマット
application/pdf
著者版フラグ
publisher
権利情報
This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. © 2020 The Authors. Journal of Applied Clinical Medical Physics published by Wiley Periodicals, Inc. on behalf of American Association of Physicists in Medicine.
関連情報URL
部局名
医系科学研究科
病院