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ID 29245
本文ファイル
著者
Hatakeyama, Tsuyoshi
Kitamura, Shosuke
Mitsui, Fukiko
Takahashi, Shoichi
Maekawa, Toshiro
Tateno, Chise
Wakita, Takaji
キーワード
Superinfection
JFH-1
IFN-stimulated genes
NDC
医学
抄録(英)
Background/Aims: Both hepatitis B virus (HBV) and hepatitis C virus (HCV) replicate in the liver and show resistance against innate immunity and interferon (IFN) treatment. Whether there is interference between these two viruses is still controversial. We investigated the interference between these two viruses and the mode of resistance against IFN. Methods: We performed infection experiments with either or both of the two hepatitis viruses in human hepatocyte chimeric mice. Huh7 cell lines with stable production of HBV were also established and transfected with HCV JFH1 clone. Mice and cell lines were treated with IFN. The viral levels in mice sera and culture supernatants and messenger RNA levels of IFN-stimulated genes were measured. Results: No apparent interference between the two viruses was seen ill vivo. Only a small (0.3 log) reduction in serum HBV and a rapid reduction in HCV were observed after IFN treatment, regardless of infection with the other virus. In ill vitro studies, no interference between the two viruses was observed. The effect of IFN on each virus was not affected by the presence of the other virus. IFN-induced reductions of viruses in culture supernatants were similar to those in ill vivo study. Conclusions: No interference between the two hepatitis viruses exists in the liver in the absence of hepatitis. The mechanisms of IFN resistance of the two viruses target different areas of the IFN system.
掲載誌名
Journal of Hepatology
51巻
6号
開始ページ
1046
終了ページ
1054
出版年月日
2009-12
出版者
Elsevier Science Bv
ISSN
0168-8278
NCID
出版者DOI
言語
英語
NII資源タイプ
学術雑誌論文
広大資料タイプ
学術雑誌論文
DCMIタイプ
text
フォーマット
application/pdf
著者版フラグ
author
権利情報
Copyright (c) 2009 European Association for the Study of the Liver. Published by Elsevier B.V.
関連情報URL
部局名
医歯薬学総合研究科