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ID 39615
本文ファイル
別タイトル
哺乳動物の精子形成における睾丸性ヒアルロニダーゼの役割
著者
Yamane, Jinshin
Kashiwabara, Takao
NDC
動物学
抄録(英)
1. Although the chemical action of testicular hyaluronidase peculiar to the mammal has been fairly well defined by the elaboration of numerous biochemists, its physiological significance cannot be seen as fully established.
2. The generalized concept postulated with the idea of "spreading factor", that its dispersal activity on the follicular cell-mass enclosing the ovum is a necesssary antecedent to ensure the fertilization, seems to be unjustifiable because of lack of such a cell-mass at ovulation in a number of mammalian species.
3. The object of this paper is to present the evidence of intracelullar activity of the testicular hyaluronidase indispensable for normal spermatogenesis.
4. A highly purified bovine testicular hyaluronidase was repeatedly injected to the male mouse and rabbit.
5. A remarkable disorganization was observed for a while in spermatogenic epithelia.
6. Lack of meiotic divisions or meiotic irregularities in the spermatocytes and pycnosis or nuclear fragmentation resulting further in debris formation, karyorrhexis and karyolysis of the spermatids were prevailing phenomena.
7. As a consequence, a striking decrease in number of intratubular spermatozoa and a partial infertility occurred.
8. In the sera of rabbits subjected to the injections of hyaluronidase, an antibody which inhibits the dispersal action of homologous enzyme on the follicular cell-mass of rabbit ovum was definitely demonstrated.
9. It follows, therefore, that the disintegration of spermatogenic epithelia particularly meiotic irregularities are results of inhibitory action of antibody which is formed agaist the testicular hyaluronidase administered.
10. The mechanism involved in such a relationship between spermatogenic abnormalities and antigenic effects of hyaluronidase was discussed.
掲載誌名
広島大学水畜産学部紀要
1巻
3号
開始ページ
321
終了ページ
336
出版年月日
1957-12-25
出版者
広島大学水畜産学部
ISSN
0440-8756
NCID
言語
英語
NII資源タイプ
紀要論文
広大資料タイプ
学内刊行物(紀要等)
DCMIタイプ
text
フォーマット
application/pdf
著者版フラグ
publisher
部局名
生物圏科学研究科
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