Expression of RANKL and Proliferation Abilities of Cultured Human Middle Ear Cholesteatoma Epithelial Cells
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ID | 35022 |
本文ファイル | |
著者 | |
キーワード | Cholesteatoma
Lipopolysaccharide
RANKL
Dexamethasone
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NDC |
医学
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抄録(英) | One of the most distinct characteristics of middle ear cholesteatomas is their capacity for bone destruction during the growth process. In this study, we examined the relationship between inflammatory mechanisms and both bone absorption and the proliferation of epithelial cholesteatoma cells. Cultured cholesteatoma epithelial cells were stimulated by lipopolysaccharide (LPS) and dexamethasone (Dex). We found that the expression of receptor activator of NF-κB ligand (RANKL) and Ki-67 in cultured cholesteatoma cells was increased by LPS stimulation, indicating that LPS promotes not only bone destruction but also the proliferative activities of these cells. The constitutive expression of RANKL and Ki-67 and the production of IL-6 and IL-8 were significantly inhibited by Dex treatment. Further, Dex significantly suppressed the stimulatory effects of LPS on RANKL and Ki-67 expression and on IL-6 and IL-8 production. Based on results so far, Dex likely exerts a beneficial action against acute inflammation. However, further studies might be required to assess its clinical features.
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掲載誌名 |
Hiroshima Journal of Medical Sciences
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巻 | 62巻
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号 | 1号
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開始ページ | 1
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終了ページ | 6
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出版年月日 | 2013-03
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出版者 | Hiroshima University Medical Press
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ISSN | 0018-2052
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NCID | |
言語 |
英語
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NII資源タイプ |
紀要論文
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広大資料タイプ |
学内刊行物(紀要等)
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DCMIタイプ | text
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フォーマット | application/pdf
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著者版フラグ | publisher
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権利情報 | (c) Hiroshima University Medical Press.
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部局名 |
医歯薬保健学研究科
医歯薬学総合研究科
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他の一覧 |