Influences of Pyrexia and Age on Theophylline Clearance in Young Children with Asthma
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ID | 35006 |
本文ファイル | |
著者 |
Imai, Keisuke
Munehisa, Yumiko
Yoshikuni, Yoshiko
Morita, Tadayuki
Nomura, Hiroaki
Mimaki, Yuichi
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キーワード | Theophylline
Children
Pyrexia
Clearance
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NDC |
医学
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抄録(英) | Fifty hospitalized children with asthmatic bronchitis and bronchial asthma were treated with a continuous intravenous drip infusion of aminophylline. To investigate the pharmacokinetics of theophylline in the presence of pyrexia, patients were divided into two groups based on body temperature: a pyrexia group (≥ 38°C) and a non-pyrexia group (< 38°C). Theophylline clearance was 0.064 ± 0.017 liters/kg/hr in the non-pyrexia group and 0.049 ± 0.010 liters/kg/hr in the pyrexia group. Theophylline clearance in the non-pyrexia and pyrexia groups was 0.044 ± 0.007 liters/kg/hr and 0.030 ± 0.009 liters/kg/hr (≤ 6 months), 0.071 ± 0.011 liters/kg/hr and 0.047 ± 0.008 liters/kg/hr (6 to ≤ 12 months), 0.084 ± 0.012 liters/kg/hr and 0.055 ± 0.006 liters/ kg/hr (1 to ≤ 2 years), and 0.065 ± 0.007 liters/kg/hr and 0.051 ± 0.001 liters/kg/hr (2 to ≤ 3 years), respectively. In all age groups, theophylline clearance of the pyrexia group was significantly less than that of the non-pyrexia group (p < 0.01), showing that there was a significant pharmacokinetic difference in theophylline clearance between the groups. Multivariate statistical analysis showed that theophylline clearance was affected by pyrexia and age. This study showed that the presence of pyrexia decreases theophylline clearance, and that it affects theophylline clearance in an age-dependent manner. Based on the results of this study, dosages should be designed based on the clearance at the time of pyrexia.
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掲載誌名 |
Hiroshima Journal of Medical Sciences
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巻 | 61巻
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号 | 1号
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開始ページ | 15
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終了ページ | 18
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出版年月日 | 2012-03
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出版者 | Hiroshima University Medical Press
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ISSN | 0018-2052
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NCID | |
言語 |
英語
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NII資源タイプ |
紀要論文
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広大資料タイプ |
学内刊行物(紀要等)
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DCMIタイプ | text
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フォーマット | application/pdf
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著者版フラグ | publisher
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権利情報 | (c) Hiroshima University Medical Press.
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部局名 |
医歯薬学総合研究科
病院
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他の一覧 |