Prognostic Significance of Expression Patterns of EGFR Family, p21 and p27 in High-grade Astrocytoma
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ID | 34983 |
本文ファイル | |
著者 |
Nabika, Shinya
Kiya, Katsuzo
Satoh, Hideki
Mizoue, Tatsuya
Kondo, Hiroshi
Katagiri, Masaya
Nishisaka, Takashi
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キーワード | EGFR
p27
p21
High-grade astrocytoma
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NDC |
医学
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抄録(英) | The goal of this study was to investigate the relationship among immunohistochemical expression of epithelial growth factor receptor (EGFR) family proteins, p21, p27 and prognosis in patients with high-grade astrocytoma. Expression of EGFR family proteins (c-erbB-1, c-erbB-2, c-erbB-3, c-erbB-4), p21 and p27 and Ki-67 labeling index (LI) were studied in 59 samples of high-grade astrocytoma. Expression of protein levels was analyzed by immunohistochemical staining of formalin-fixed and paraffin-embedded sections. Results were analyzed in relation to age, gender and survival. Overexpression of c-erbB-1, c-erbB-2, c-erbB-3 and c-erbB-4 was found in 40 (67.8%), 17 (28.8%), 3 (5.1 %) and 42 (75.0%) samples, respectively. Similarly, low expression of p21 and p27 was observed in 50 (84.8%) and 27 (45.8%) samples. Mean Ki-67 LI was 17.3 ± 1.1. Cox multiple regression analysis showed that c-erbB-1 (Hazard rate(HR) 1.57, 95% Confidence interval (Cl) 1.08-2.36; p=0.017), c-erbB-4 (HR 1.79, 95%CI 1.20- 2. 7 4; p=0.004) and p27 (HR 0.50, 95%CI 0.30-0.82; p=0.006) were significantly associated with survival. High expression of c-erbB-1 and c-erbB-4 and low expression of p27 were associated with poor prognosis in these patients.
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掲載誌名 |
Hiroshima Journal of Medical Sciences
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巻 | 59巻
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号 | 4号
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開始ページ | 65
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終了ページ | 70
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出版年月日 | 2010-12
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出版者 | Hiroshima University Medical Press
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ISSN | 0018-2052
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NCID | |
言語 |
英語
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NII資源タイプ |
紀要論文
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広大資料タイプ |
学内刊行物(紀要等)
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DCMIタイプ | text
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フォーマット | application/pdf
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著者版フラグ | publisher
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権利情報 | (c) Hiroshima University Medical Press.
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部局名 |
医歯薬学総合研究科
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他の一覧 |