Fine Structural Aspects of the Urothelium in the Mouse Ureter with Special Reference to Cell Kinetics
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ID | 37676 |
本文ファイル | |
著者 |
Yamashita, Keisuke
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キーワード | Ureter
Epithelium
Cell kinetics
Mice
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NDC |
医学
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抄録(英) | The present study aimed at clarifying the cell kinetics of the mouse ureteral epithelium by focusing on vesicle maturation in the cells and labeling with bromodeoxyuridine (BrdU). Electron microscopically, superficial cells were characterized by concave plaques in the apical plasma membrane and numerous fusiform vesicles in the cytoplasm. Intermediate cells were laden with ellipsoid vesicles, and basal cells had a few or no round vesicles. From the difference in number and form of vesicles among the three types of cells, it can be inferred that intermediate cells are immature in comparison with superficial cells, and likewise basal cells in comparison with intermediate cells. When BrdU was injected intraperitoneally once a day for seven days, most BrdU-labeled cells were located in the basal layer. Twelve days after the last injection, BrdU was detected in the intermediate or superficial layer in addition to the basal layer. These findings suggest that the basal cell is a progenitor cell giving rise to daughter cells that migrate upward to replace intermediate and superficial cells.
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内容記述 | This work was supported in part by Grants-in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science and Technology of Japan, and by Health Science Research Grants for Research on Environmental Health from the Ministry of Health, Labour and Welfare of Japan.
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掲載誌名 |
Hiroshima Journal of Medical Sciences
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巻 | 51巻
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号 | 2号
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開始ページ | 41
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終了ページ | 48
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出版年月日 | 2002-06
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出版者 | Hiroshima University Medical Press
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ISSN | 0018-2052
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NCID | |
言語 |
英語
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NII資源タイプ |
紀要論文
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広大資料タイプ |
学内刊行物(紀要等)
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DCMIタイプ | text
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フォーマット | application/pdf
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著者版フラグ | publisher
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部局名 |
医歯薬学総合研究科
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他の一覧 |