このエントリーをはてなブックマークに追加
ID 37676
本文ファイル
著者
Yamashita, Keisuke
キーワード
Ureter
Epithelium
Cell kinetics
Mice
NDC
医学
抄録(英)
The present study aimed at clarifying the cell kinetics of the mouse ureteral epithelium by focusing on vesicle maturation in the cells and labeling with bromodeoxyuridine (BrdU). Electron microscopically, superficial cells were characterized by concave plaques in the apical plasma membrane and numerous fusiform vesicles in the cytoplasm. Intermediate cells were laden with ellipsoid vesicles, and basal cells had a few or no round vesicles. From the difference in number and form of vesicles among the three types of cells, it can be inferred that intermediate cells are immature in comparison with superficial cells, and likewise basal cells in comparison with intermediate cells. When BrdU was injected intraperitoneally once a day for seven days, most BrdU-labeled cells were located in the basal layer. Twelve days after the last injection, BrdU was detected in the intermediate or superficial layer in addition to the basal layer. These findings suggest that the basal cell is a progenitor cell giving rise to daughter cells that migrate upward to replace intermediate and superficial cells.
内容記述
This work was supported in part by Grants-in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science and Technology of Japan, and by Health Science Research Grants for Research on Environmental Health from the Ministry of Health, Labour and Welfare of Japan.
掲載誌名
Hiroshima Journal of Medical Sciences
51巻
2号
開始ページ
41
終了ページ
48
出版年月日
2002-06
出版者
Hiroshima University Medical Press
ISSN
0018-2052
NCID
言語
英語
NII資源タイプ
紀要論文
広大資料タイプ
学内刊行物(紀要等)
DCMIタイプ
text
フォーマット
application/pdf
著者版フラグ
publisher
部局名
医歯薬学総合研究科
他の一覧