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ID 37720
本文ファイル
著者
Yamashita, Shoko
Nagai, Nobutaka
Oshita, Takafumi
Sakata, Kenichiro
Murakami, Tomohiro
Shigemasa, Kazushi
Tanioka, Yoshihide
Inai, Kouki
Ohama, Koso
キーワード
Adenoma malignum
Clinicocytopathological study
Immunohistochemical study
HIK 1083
NDC
医学
抄録(英)
Adenoma malign um is a rare type of very highly differentiated adenocarcinoma of the uterine cervix, and is quite difficult to diagnose because there are few findings definitely suggesting malignancy on cytologic or histologic examination. We recently encountered four patients with adenoma malignum and reviewed their clinicocytopathological and immunohistochemical findings. The most characteristic symptom was a watery discharge and an enlarged cervix was palpable, while multiple cystic lesions (MCL) were observed by transvaginal and abdominal ultrasonography, CT or MRI. On cytodiagnosis, the cervical gland cells formed large sheets or showed a palisading arrangement. Slightly enlarged nuclei and yellowish-orange staining of the cytoplasmic mucus were the characteristic findings. On histological examination, many cervical glands of different sizes were present and extended deep into the muscle layer, while branching or papillary growth into the lumen was also observed.  

On immunohistochemical study, HIK1083, a monoclonal antibody for gastric gland mucous cell mucin, was found to be positive in 3 of 4 cases, and this was fairly useful in the diagnosis of adenoma malignum.
掲載誌名
Hiroshima Journal of Medical Sciences
49巻
4号
開始ページ
167
終了ページ
173
出版年月日
2000-12
出版者
Hiroshima University Medical Press
ISSN
0018-2052
NCID
言語
英語
NII資源タイプ
紀要論文
広大資料タイプ
学内刊行物(紀要等)
DCMIタイプ
text
フォーマット
application/pdf
著者版フラグ
publisher
部局名
医歯薬学総合研究科
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