このエントリーをはてなブックマークに追加
ID 37815
本文ファイル
著者
Ueda, Hironori
Imazu, Michinori
Hayashi, Yasuhiko
Ono, Koichi
Yasui, Wataru
Yamakido, Michio
キーワード
Proliferating cell nuclear antigen (PCNA)
Directional coronary atherectomy (DCA)
Acute coronary syndromes
Restenosis
NDC
医学
抄録(英)
The overgrowth of cells of the vessel wall, especially of the smooth muscle cells (SMCs), contributes to the pathogenesis of coronary atherosclerosis and wound repair after coronary angioplasty. However, the association between cellular proliferation in coronary lesions and clinical pathophysiology remains to be clarified in humans. Thus, we investigated proliferative activity in coronary tissues obtained from patients with coronary ischemia. The proliferative activity in tissues obtained by using directional coronary atherectomy (DCA) from 87 coronary lesions was assessed by immunohistochemical staining for the proliferating cell nuclear antigen (PCNA). The lesions were divided into 34 primary lesions and 53 postangioplasty lesions. The 34 primary tissue samples were obtained from 9 patients with stable angina pectoris (SAP) and 25 patients with acute coronary syndromes (ACS). Collectively, the 53 postangioplasty tissue samples were obtained from 37 patients with SAP and 16 patients with ACS. The PCNA labeling index (LI) was quantified as the mean percentage of PCNA-positive cells in the 3 most positive high-power fields (×200). The mean Lis were high in the primary ACS samples [8.9 ± 2.1 % (p=0.01)] and postangioplasty samples [2.3 ± 0.8% (p=0.08) in SAP cases and 4.1 ± 2.4% (p=0.06) in ACS cases] compared with the primary SAP samples (0.2 ± 0.2%). Intimal hyperplasia, a random proliferation of SMCs (a-actin positive) was marked in the primary ACS samples (76%) as well as in the postangioplasty SAP (92%) and ACS (81 %) samples, as compared with the primary SAP samples (33%) (p<0.01). PCNA expression was mainly evident in the nucleus of the SMCs and CD68-positive macrophages. Many PCNA-positive cells were localized in plaque areas, as follows: intimal hyperplasia, neovascularized lesions, lesions with macrophage clusters, and lesions near areas of disrupted internal elastic lamina. The levels of PCNA expression in coronary lesions were not associated with the subsequent development of restenosis after DCA. Our findings suggest that the excessive proliferation of vascular wall cells, especially SMCs, is involved in the pathogenesis of ACS and in the process of wound repair after angioplasty in humans.
内容記述
This work was supported in part by grants from the Tsuchiya foundation.
掲載誌名
Hiroshima Journal of Medical Sciences
46巻
1号
開始ページ
31
終了ページ
42
出版年月日
1997-03
出版者
Hiroshima University Medical Press
ISSN
0018-2052
NCID
言語
英語
NII資源タイプ
紀要論文
広大資料タイプ
学内刊行物(紀要等)
DCMIタイプ
text
フォーマット
application/pdf
著者版フラグ
publisher
部局名
医歯薬学総合研究科
他の一覧