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ID 38005
本文ファイル
著者
Hossain, Md. Delawar
Fujii, Kohyu
Yuge, Osafumi
Kawahara, Michio
Morio, Michio
キーワード
Anesthetics, volatile: sevoflurane.
Biotransformation: fluorometabolites.
Ions, fluoride: excretion.
NDC
医学
抄録(英)
Serum concentrations and urinary excretion of inorganic fluoride (fluoride ion), a metabolite of sevofluorane, were measured by an ion-chromatographic analyzer after inhalation of three different concentrations of sevoflurane in adult, male Japanese white rabbits weighing 2.6-3.6 kg. Sevoflurane was administered at concentrations of 0% (control), 1%, 2% and 3% (Groups I, II, III and IV, respectively) through a sevoflurane vaporizer for 2 hr under controled ventilation. Blood and urine samples were collected during and after termination of sevoflurane inhalation at scheduled time intervals for 24 hr. The total volume of urine, the urinary pH and the osmolality of serum and urine were not significantly different among any of the groups. Osmolality of the serum and urine was within normal range in all groups of animals. The mean serum peak values of fluoride ion were 0.7±0.5, 22.8±8.7, 31.8±11.0 and 41.5±13.2 μM (mean± SD) in groups I, II, III and IV, respectively. Peak values were recorded within 15 min after the termination of inhalation. The cumulative amounts of fluoride ion excreted in urine in 24 hr were calculated to be 5.0±1.6, 26.1±6.7, 41.4±11.3 and 64.3±18.0 μmol (mean±SD) in groups I, II, III and IV, respectively. Regression analysis revealed significant correlations between the formation and excretion of fluoride ion, and the dose of sevoflurane (r=0.85, p<0.05 and r=0.89, p<0.05, respectively). The authors conclude that the formation and excretion of fluoride ion after sevoflurane anesthesia is dependent on the dose of the drug. This study also concludes that 1-3% of sevoflurane for 2 hr of inhalation is unlikely to produce renal dysfunction.
内容記述
This study was supported in part by a Research Grant from the Japanese Ministry of Education, Science and Culture.
掲載誌名
Hiroshima Journal of Medical Sciences
40巻
1号
開始ページ
1
終了ページ
7
出版年月日
1991-03
出版者
Hiroshima University Medical Press
ISSN
0018-2052
NCID
PubMedID
言語
英語
NII資源タイプ
紀要論文
広大資料タイプ
学内刊行物(紀要等)
DCMIタイプ
text
フォーマット
application/pdf
著者版フラグ
publisher
部局名
医歯薬学総合研究科
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