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ID 49893
本文ファイル
著者
OKIDA, Motoichi
KIKUCHI, Hirosato
FUJII, Kohyu
キーワード
Biotransformation
Concentration-dependence
Halothane
NDC
医学
抄録(英)
Effect of end-expiratory halothane concentration on its aerobic and anaerobic metabolism was studied in 20 male rabbits.
Biliary excretion of trifluoroacetic acid (TF AA), an aerobic metabolite of halothane, and the pulmonary excretion of CF2CHCl (CDFF) and CF3CH2Cl (CTFE), anaerobic metabolites of halothane, were measured simultaneously during 5 hr of inhalation at various concentrations of halothane (0.02-1.5%).
The total amount of biliary TF AA excreted for 5 hr remained unchanged (38.4μmol- 44.lμmol) at each concentration except 0.02%. However, the total amount of CDFE and CTFE excreted for 5 hr increased in a concentration-dependent manner up to 0.5% end-expiratory halothane, and remained unchanged (47.2μmol-64.7μmol) at more than 0.5%. Total biliary excretion of TF AA reached its maximum at a 0.05%.
These results suggest that the primary route of halothane metabolism at a subanesthetic concentration is the aerobic pathway which produces TF AA. However, at anesthetic concentration exceeding 0.5%, the anaerobic route which produces volatile CDFE and CTFE plays a role also as an aerobic route.
内容記述
This study was supported in part by Science Research Grants from the Ministry of Education, Science and Culture of Japan
掲載誌名
Hiroshima Journal of Medical Sciences
35巻
1号
開始ページ
15
終了ページ
20
出版年月日
1986-03
出版者
Hiroshima University School of Medicine
ISSN
0018-2052
NCID
PubMedID
言語
英語
NII資源タイプ
紀要論文
広大資料タイプ
学内刊行物(紀要等)
DCMIタイプ
text
フォーマット
application/pdf
著者版フラグ
publisher
部局名
医歯薬学総合研究科
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