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ID 38380
本文ファイル
別タイトル
Anti-microtubular agent のアロキサンによるインスリン分泌およびブドウ糖によるインスリン分泌阻害に及ぼす影響
著者
Ishibashi, Fukashi
キーワード
Alloxan
Anti-microtubular agents
Glucose-induced insulin release
Pancreatic islets
NDC
医学
抄録(英)
The effect of various anti-microtubular agents on alloxan stimulation and inhibition of a subsequent glucose-induced insulin release was investigated using in vitro incubation and perifusion of rat isolated islets of Langerhans. Five minute exposure of islets to alloxan (20 mg/dl) induced a transient burst of insulin release which was eliminated by the pretreatment of islets by heavy water (D2O) or colchicine (10-3 M) and concomitant presence of them with alloxan. However, vincristine (10-4 M) did not affect alloxan actions.

A brief exposure .of islets to alloxan completely inhibited a subsequent glucose (16.7 mM)-induced insulin release. The pretreatment of islets with D2O or colchicine prevented alloxan inhibition of insulin release, whereas vincristine did not demonstrate
such an action.

Because the transport of pyrimidine was completely inhibited by anti-microtubular agents, it seems likely that the transport of alloxan (2, 4, 5, 6-tetraoxypyrimidine, 5, 6-dioxyuracil) into the B-cell is impaired by these agents. Otherwise, anti-microtubular agents reduced the generation of highly reactive oxygen-containing free radicals from alloxan, which inhibits the glucose-induced insulin release.
掲載誌名
Hiroshima Journal of Medical Sciences
31巻
2号
開始ページ
91
終了ページ
95
出版年月日
1982-06-10
出版者
Hiroshima University School of Medicine
ISSN
0018-2052
NCID
PubMedID
言語
英語
NII資源タイプ
紀要論文
広大資料タイプ
学内刊行物(紀要等)
DCMIタイプ
text
フォーマット
application/pdf
著者版フラグ
publisher
部局名
医歯薬学総合研究科
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