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ID 38418
本文ファイル
別タイトル
コンカナバリンA刺激時の多核白血球超酸化物イオン放出に及ぼすサイトカラシンAの増強効果
著者
Matsuura, Ryoji
NDC
医学
抄録(英)
Superoxide anion release from polymorphonuclear leukocytes stimulated by concanavalin A was markedly enhanced by the simultaneous addition of cytochalasin A at concentrations of 2×10-8 to 4×10-7M. These concentrations of cytochalasin A did not affect the phagocytosis of diisodecyl phthalate emulsion. These concentrations were far lower than those of cytochalasins B, C, D and E that also enhanced concanavalin A-induced superoxide anion release. Superoxide anion release stimulated by concanavalin A and cytochalasin A required the binding of concanavalin A on the cell membrane, and was dependent on the existence of extracellular Ca2+. The enhancement by cytochalasin A was reversible. It is suggested that cytochalasin A acts not only as a sulfhydryl reagent as reported previously, but also has actions resembling the other cytochalasins.
内容記述
This work has been supported in part by Grants-in-Aid for Scientific Research (Project Nos. 544050, 448227) from the Ministry of Education, Science and Culture of Japan and a Grant-in-Aid from the Japan Medical Research Foundation.
掲載誌名
Hiroshima Journal of Medical Sciences
30巻
3号
開始ページ
229
終了ページ
236
出版年月日
1981-09-10
出版者
Hiroshima University School of Medicine
ISSN
0018-2052
NCID
PubMedID
言語
英語
NII資源タイプ
紀要論文
広大資料タイプ
学内刊行物(紀要等)
DCMIタイプ
text
フォーマット
application/pdf
著者版フラグ
publisher
部局名
医歯薬学総合研究科
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