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ID 30879
本文ファイル
著者
Yamamoto, Shigeto
Morinobu, Shigeru
Iwamoto, Yasuyuki
Ueda, Yuto
Takei, Shiro
Fujita, Yosuke
キーワード
Single prolonged stress
Fear extinction
Glycine
Glycine transporter 1
Hippocampus
Posttraumatic stress disorder
NDC
医学
抄録(英)
Previous studies have demonstrated that rats subjected to single prolonged stress (SPS) exhibit posttraumatic stress disorder (PTSD)-like symptoms such as enhanced contextual fear in response to trauma related and trauma-unrelated events Furthermore we previously reported that upregulation of hippocampal glycine transporter 1 (GlyT-1) mRNA after context exposure could be the initial mechanism underlying impaired fear extinction in SPS rats To clarify the involvement of the hippocampal glycinergic system in impaired fear extinction in SPS rats we measured the time course of changes in the duration of freezing, and the hippocampal levels of Gly-T1 mRNA using contextual fear conditioning (FC) and extinction training We also used in vivo microdialysis to measure the concentration of extracellular glycine in the hippocampus during the time interval between FC and the first context exposure SPS rats exhibited increased and sustained contextual fear responses The enhanced contextual fear response in SPS rats was associated with a sustained increase in hippocampal levels of Gly-T1 mRNA after FC relative to sham rats and by a decrease in the extracellular glycine concentration GlyT-1 mRNA levels in rats that underwent repeated extinction training were significantly lower than in rats that did not undergo extinction training These findings indicate that reduced activity of the hippocampal glycinergic system could be closely involved in impaired fear extinction in SPS rats suggesting that activation of the glycinergic system by D-cycloserine or GlyT-1 inhibitors may ameliorate the impairment of fear extinction.
掲載誌名
Journal of Psychiatric Research
44巻
15号
開始ページ
1069
終了ページ
1074
出版年月日
2010-11
出版者
Pergamon Elsevier Science Ltd
ISSN
0022-3956
NCID
出版者DOI
言語
英語
NII資源タイプ
学術雑誌論文
広大資料タイプ
学術雑誌論文
DCMIタイプ
text
フォーマット
application/pdf
著者版フラグ
author
権利情報
Copyright (c) 2010 Elsevier Ltd.
関連情報URL
部局名
医歯薬学総合研究科