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ID 30414
本文ファイル
著者
Fujikawa, Tokumi
Takami, Hiroshi
Yanai, Ichiro
Morinobu, Shigeru
キーワード
elderly
major depression
silent cerebral infarction
magnetic resonance imaging
prognosis
dementia
NDC
医学
抄録
.
抄録(英)
OBJECTIVE: Many studies have examined the effects of cerebrovascular change on treatment response in geriatric depression. However, few such studies have examined the relationship between cerebrovascular changes and long term prognosis. We examined the effects of cerebrovascular change on the course of geriatric depressive symptoms, dementia rates, and mortality over a follow-up period of approximately 10 years.

METHOD: Participants were 84 patients with major depression (age of onset greater than 50 years old); patients suffering from strokes, neurological disorders, and other psychiatric disorders were excluded. MRI findings were used to classify all patients into silent cerebral infarction (SCI) positive (n = 37) or negative groups (n = 47). Patient prognoses were ascertained using a review of clinical charts and over the mail.

RESULTS: Only 5% of patients with SCI were able to maintain remission, whereas 36% of those patients without SCI were able to do so. Total duration of depressive episodes was significantly longer in the SCI positive group than in the SCI negative group. In addition, SCI was associated with a higher risk of the onset of dementia.

CONCLUSION: The results of this long-term follow-up study demonstrate that the presence of SCI is associated with a relatively poor prognosis for geriatric depression
掲載誌名
Neuropsychobiology
62巻
3号
開始ページ
177
終了ページ
181
出版年月日
2010
出版者
Karger
ISSN
0302-282X
NCID
出版者DOI
言語
英語
NII資源タイプ
学術雑誌論文
広大資料タイプ
学術雑誌論文
DCMIタイプ
text
フォーマット
application/pdf
著者版フラグ
author
権利情報
Copyright (c) 2010 S. Karger AG, Basel
関連情報URL
部局名
医歯薬学総合研究科