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ID 38136
本文ファイル
著者
Sumiyoshi, Hiromichi
Oda, Noriko
Miyamori, Shinji
Kameda, Takashi
Takekura, Naoki
Takanashi, Atsushi
Tahara, Eiichi
キーワード
Human epidermal growth factor
DNA synthesis
Gastrointestinal mucosa
NDC
医学
抄録(英)
Interaction between epidermal growth factor (EGF) and gastrin on DNA synthesis of the rat gastrointestinal tract was examined. Fasted male rats were divided into four groups and injected with 10 μg/kg human EGF, 300 μg/kg pentagastrin, human EGF plus pentagastrin and saline (control), respectively. The animals were sacrificed 8 or 16 hr thereafter and the incorporation of [3H]thymidine into the gastrointestinal mucosa was measured. Human EGF increased DNA synthesis of the fundus, antrum and cecum, while pentagastrin stimulated that of the fundus, duodenum, ileum and proximal colon. Synchronous administration of these peptides also stimulated DNA synthesis of the fundus, antrum and cecum. However, in the ileum and proximal colon, DNA synthesis stimulated by pentagastrin was suppressed by the administration of both agents synchronously. These data suggest that these growth factors regulate the growth of gastrointestinal tract with complex interactions.
内容記述
This work was supported by Grant-in Aid for Cancer Research from the Ministry of Education, Science and Culture of Japan (59010074, 60010075).
掲載誌名
Hiroshima Journal of Medical Sciences
37巻
1号
開始ページ
1
終了ページ
6
出版年月日
1988-03
出版者
Hiroshima University Medical Press
ISSN
0018-2052
NCID
PubMedID
言語
英語
NII資源タイプ
紀要論文
広大資料タイプ
学内刊行物(紀要等)
DCMIタイプ
text
フォーマット
application/pdf
著者版フラグ
publisher
部局名
医歯薬学総合研究科
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