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ID 30863
本文ファイル
著者
Sakamoto, Naoya
Anami, Katsuhiro
Naito, Yutaka
Aoyagi, Kazuhiko
Sasaki, Hiroki
キーワード
Gastric cancer
Intestinal phenotype
Connexin 30
Microarray
NDC
医学
抄録(英)
Aims: The mucin phenotype is associated with clinicopathological findings and tumorigenesis in gastric cancer (GC). The aim was to search for a novel marker regulating the intestinal phenotype of GC. Methods and Results: We performed microarray analyses, and GJB6 (encoding connexin 30) was identified as a gene associated with the intestinal phenotype. Immunostaining of connexin 30 in 169 GC cases revealed that 47 (28%) cases were positive for connexin 30, while connexin 30 was negative in nonneoplastic gastric tissue. Connexin 30-negative GC cases showed more advanced T grade, N grade, and tumor stage than connexin 30-positive GC cases. Six (13%) GC cases positive for connexin 30 were histologically of the differentiated type. In addition, the expression of gastric and intestinal phenotypes of GC was examined by immunostaining for MUC5AC, MUC6, MUC2, and CD10. Connexin 30 expression occurred more frequently in the intestinal phenotype (48%) than in other phenotypes (21%) of GC. Conclusion: These results indicate that the expression of connexin 30 is a novel differentiation marker mediating the biological behavior of intestinal phenotype GC.
掲載誌名
Pathobiology
77巻
5号
開始ページ
241
終了ページ
248
出版年月日
2010
出版者
Karger
ISSN
1015-2008
NCID
出版者DOI
言語
英語
NII資源タイプ
学術雑誌論文
広大資料タイプ
学術雑誌論文
DCMIタイプ
text
フォーマット
application/pdf
著者版フラグ
author
権利情報
Copyright (c) 2010 S. Karger AG, Basel
関連情報URL
部局名
医歯薬学総合研究科