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ID 26303
本文ファイル
著者
Akagi, Nana
Anniko, Matti
キーワード
endolymphatic hydrops
lipopolysaccharide
aldosterone
mice
Ménière's disease
NDC
医学
抄録(英)
Conclusion. A new mouse model for Ménière's disease has been developed by the treatment with both LPS and aldosterone. The induction of vestibular dysfunction in the hydropic animals model may require additional stress such as reduced inner ear blood flow, acute changes of endolymph volume and/or pressure, etc. Objective. The aim of this study is to develop a more suitable animal model, which shows more resemblance to the pathophysiological process in Ménière's disease. Materials and methods. Adult CBA/J mice were treated with intratympanic injection of LPS, intraperitoneal injection of aldosterone or injection of both LPS and aldosterone. Morphological analysis was performed in the cochlea and endolymphatic sac. Results. All experimental animals showed mild to moderate endolymphatic hydrops. The animals treated with both LPS and aldosterone showed reversible vestibular dysfunction after the intratympanic injection of epinephrine.
掲載誌名
Acta Oto-Laryngologica
128巻
3号
開始ページ
263
終了ページ
271
出版年月日
2008
出版者
Taylor & Francis
ISSN
0001-6489
NCID
出版者DOI
言語
英語
NII資源タイプ
学術雑誌論文
広大資料タイプ
学術雑誌論文
DCMIタイプ
text
フォーマット
application/pdf
著者版フラグ
author
権利情報
Copyright (c) 2008 Taylor & Francis
関連情報URL
部局名
医歯薬学総合研究科