A new animal model for Ménière's disease
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ID | 26303 |
本文ファイル | |
著者 |
Akagi, Nana
Anniko, Matti
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キーワード | endolymphatic hydrops
lipopolysaccharide
aldosterone
mice
Ménière's disease
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NDC |
医学
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抄録(英) | Conclusion. A new mouse model for Ménière's disease has been developed by the treatment with both LPS and aldosterone. The induction of vestibular dysfunction in the hydropic animals model may require additional stress such as reduced inner ear blood flow, acute changes of endolymph volume and/or pressure, etc. Objective. The aim of this study is to develop a more suitable animal model, which shows more resemblance to the pathophysiological process in Ménière's disease. Materials and methods. Adult CBA/J mice were treated with intratympanic injection of LPS, intraperitoneal injection of aldosterone or injection of both LPS and aldosterone. Morphological analysis was performed in the cochlea and endolymphatic sac. Results. All experimental animals showed mild to moderate endolymphatic hydrops. The animals treated with both LPS and aldosterone showed reversible vestibular dysfunction after the intratympanic injection of epinephrine.
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掲載誌名 |
Acta Oto-Laryngologica
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巻 | 128巻
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号 | 3号
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開始ページ | 263
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終了ページ | 271
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出版年月日 | 2008
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出版者 | Taylor & Francis
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ISSN | 0001-6489
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NCID | |
出版者DOI | |
言語 |
英語
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NII資源タイプ |
学術雑誌論文
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広大資料タイプ |
学術雑誌論文
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DCMIタイプ | text
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フォーマット | application/pdf
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著者版フラグ | author
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権利情報 | Copyright (c) 2008 Taylor & Francis
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関連情報URL | |
部局名 |
医歯薬学総合研究科
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