Telomere G-tail Length is a Promising Biomarker Related to White Matter Lesions and Endothelial Dysfunction in Patients With Cardiovascular Risk: A Cross-sectional Study
この文献の参照には次のURLをご利用ください : https://ir.lib.hiroshima-u.ac.jp/00048649
ID | 48649 |
本文ファイル | |
著者 |
Hosomi, Naohisa
大学院医歯薬保健学研究科(医)
Takahashi, Tetsuya
病院(医)
Anno, Kumiko
大学院医歯薬保健学研究院(薬)
Aoki, Shiro
Shimamoto, Akira
大学院医歯薬保健学研究科(薬)
Hayashi, Tomonori
Matsumoto, Masayasu
大学院医歯薬保健学研究院(医)
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キーワード | Endothelial dysfunction
Telomere lengths
Telomere G-tail lengths
White matter changes
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抄録(英) | Background: The telomeric 3′-overhang (G-tail) length is essential for the biological effects of telomere dysfunction in vitro, but the association of length with aging and cardiovascular risk is unclear in humans. We investigated the association between the telomere G-tail length of leukocytes and cardiovascular risk, age-related white matter changes (ARWMCs), and endothelial function.
Methods: Patients with a history of cerebrovascular disease and comorbidity were enrolled (n = 102; 69 males and 33 females, 70.1 ± 9.2 years). Total telomere and telomere G-tail lengths were measured using a hybridization protection assay. Endothelial function was evaluated by ultrasound assessment of brachial flow-mediated dilation (FMD). Findings: Shortened telomere G-tail length was associated with age and Framingham risk score (P = 0.018 and P = 0.012). In addition, telomere G-tail length was positively correlated with FMD values (P = 0.031) and negatively with the severity of ARWMCs (P = 0.002). On multivariate regression analysis, telomere G-tail length was independently associated with FMD values (P = 0.022) and the severity of ARWMCs (P = 0.033), whereas total telomere length was not associated with these indicators. Interpretation: Telomere G-tail length is associated with age and vascular risk factors, and might be superior to total telomere length as a marker of endothelial dysfunction and ARWMC severity. |
内容記述 | This study was supported in part by research grants from the Smoking Research Foundation, the Tsuchiya Foundation, the Japan Science and Technology Agency, the Japan Heart Foundation, Scientific Support Programs for Cancer Research Grant-in-Aid for Scientific Research on Innovative Areas from the Ministry of Education, Culture, Sports, Science and Technology of Japan, and JSPS KAKENHI Grants-in-Aid for Scientific Research (B) (Generative Research Fields).
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掲載誌名 |
EBioMedicine
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巻 | 2巻
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号 | 8号
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開始ページ | 960
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終了ページ | 967
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出版年月日 | 2015-05
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出版者 | Elsevier B.V.
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ISSN | 2352-3964
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出版者DOI | |
PubMedID | |
言語 |
英語
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NII資源タイプ |
学術雑誌論文
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広大資料タイプ |
学術雑誌論文
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DCMIタイプ | text
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フォーマット | application/pdf
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著者版フラグ | publisher
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権利情報 | Copyright © 2015 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
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関連情報URL | |
部局名 |
医歯薬学総合研究科
病院
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