High Initial-dose Dependency of Cerebrovascular Disease Mortality among Female Survivors of the Hiroshima Atomic Bomb Exposed in Teens : A Cohort Study, 1970-2010
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ID | 40781 |
本文ファイル | |
著者 |
Matsuba, Junji
Ohtaki, Megu
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キーワード | Atomic bomb survivors
Cerebrovascular disease
Dose-response relationship
Exposure-distance
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NDC |
医学
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抄録(英) | Several studies have been conducted on cerebrovascular disease mortality in Atomic bomb survivors. Previous studies have investigated the relationship between mortality and initial radiation dose after adjusting for the effects of sex and age at the time of the bombing (ATB), and detected a weak (but statistically significant) dose-response relationship was detected. The objective of the present study was to examine whether the sex- and age ATB-specific cerebrovascular disease mortality among Hiroshima atomic bomb survivors can be explained by the initial radiation dose. At Hiroshima University, a cohort study has been conducted with Hiroshima Atomic Bomb Survivors (ABS) since 1970. We selected 30,378 subjects from the ABS who were exposed at 3.5 km or less from the hypocenter and still alive on January 1, 1970. These subjects were followed up until December 31, 2010. The cohort data were stratified with respect to sex and age ATB into 10-year age groups. For each stratum, using Cox regression, we performed survival analyses of the risk of cerebrovascular mortality using the initial radiation dose and the exposure distance (the ground distance between the exposure location and the hypocenter) as explanatory variables. The results indicated that the risks to females exposed at 10 to 19 years old were highly dependent on the initial radiation dose (hazard ratio: 1.51, p < 0.001), while the risks to males were not. There might exist some radiation exposure effects limited to women who were in their teens at the time of exposure. However, the background mechanisms remain unclear, necessitating further study.
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内容記述 | This study was supported in part by Grants-in-Aid for Scientific Research (A) 24249039, Young Scientists (B) 23790694, and 23700337 from the Japanese Ministry of Education, Culture, Sports, Science and Technology.
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掲載誌名 |
Hiroshima Journal of Medical Sciences
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巻 | 65巻
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号 | 2号
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開始ページ | 35
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終了ページ | 43
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出版年月日 | 2016-06
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出版者 | Hiroshima University Medical Press
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ISSN | 0018-2052
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NCID | |
言語 |
英語
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NII資源タイプ |
紀要論文
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広大資料タイプ |
学内刊行物(紀要等)
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DCMIタイプ | text
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フォーマット | application/pdf
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著者版フラグ | publisher
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権利情報 | Copyright (c) 2016 Hiroshima University Medical Press
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部局名 |
医歯薬学総合研究科
原爆放射線医科学研究所
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他の一覧 |