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ID 38011
本文ファイル
著者
Mikami, Takashi
Kawamoto, Keiichi
Kiya, Katsuzo
Mukada, Kazutoshi
Hotta, Takuhiro
Ogasawara, Hidenori
Uozumi, Tohru
キーワード
Medulloblastoma
Brain tumor
Xenograft
Nude mice
NDC
医学
抄録(英)
A new xenotransplantable tumor line, MED-FU, was derived from a 6-year-old female patient with cerebellar medulloblastoma. This tumor was grown in nude mice as serially transplantable subcutaneous xenografts composed of small round cells with hyperchromatic nuclei and scant cytoplasm. Many rosettes and mitoses were observed. Immunohistochemically, glial fibrillary acidic protein (GFAP), S-100 protein, and neuron specific enolase (NSE) were not detected. The doubling time of the subcutaneous tumors was 6.8 days. Highly concentrated polyamines were detected in the tumor tissue and serum of tumor-bearing mice. This xenotransplanted tumor line, MED-FU, is considered to provide an available experimental model for the study of human medulloblastoma.
掲載誌名
Hiroshima Journal of Medical Sciences
40巻
1号
開始ページ
41
終了ページ
45
出版年月日
1991-03
出版者
Hiroshima University Medical Press
ISSN
0018-2052
NCID
PubMedID
言語
英語
NII資源タイプ
紀要論文
広大資料タイプ
学内刊行物(紀要等)
DCMIタイプ
text
フォーマット
application/pdf
著者版フラグ
publisher
部局名
医歯薬学総合研究科
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