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ID 47026
本文ファイル
著者
Kanegane, Hirokazu
Hoshino, Akihiro
Okano, Tsubasa
Yasumi, Takahiro
Wada, Taizo
Takada, Hidotoshi
Okada, Satoshi 大学院医歯薬保健学研究科(医) 広大研究者総覧
Yamashita, Motoi
Yeh, Tzu-wen
Nishikomori, Ryuta
Takagi, Masatoshi
Imai, Kohsuke
Ochs, Hans D.
Morio, Tomohiro
キーワード
Flow cytometry
Intracellular protein
Monoclonal antibody
Primary immunodeficiency disease
Surface protein
NDC
医学
抄録(英)
Primary immunodeficiencies (PIDs) are a heterogeneous group of inherited diseases of the immune system. The definite diagnosis of PID is ascertained by genetic analysis; however, this takes time and is costly. Flow cytometry provides a rapid and highly sensitive tool for diagnosis of PIDs.
Flow cytometry can evaluate specific cell populations and subpopulations, cell surface, intracellular and intranuclear proteins, biologic effects associated with specific immune defects, and certain functional immune characteristics, each being useful for the diagnosis and evaluation of PIDs. Flow cytometry effectively identifies major forms of PIDs, including severe combined immunodeficiency, X-linked agammaglobulinemia, hyper IgM syndromes, Wiskott-Aldrich syndrome, X-linked lymphoproliferative syndrome, familial hemophagocytic lymphohistiocytosis, autoimmune lymphoproliferative syndrome, IPEX syndrome, CTLA 4 haploinsufficiency and LRBA deficiency, IRAK4 and MyD88 deficiencies, Mendelian susceptibility to mycobacterial disease, chronic mucocuneous candidiasis, and chronic granulomatous disease. While genetic analysis is the definitive approach to establish specific diagnoses of PIDs, flow cytometry provides a tool to effectively evaluate patients with PIDs at relatively low cost.
内容記述
This study was supported by grants from the Ministry of Education, Culture, Sports, Science, and Technology of Japan and the Ministry of Health, Labour, and Welfare of Japan.
Supplementary data related to this article can be found at http://dx.doi.org/10.1016/j.alit.2017.06.003
掲載誌名
Allergology International
67巻
1号
開始ページ
43
終了ページ
54
出版年月日
2018-01
出版者
Japanese Society of Allergology
ISSN
1323-8930
出版者DOI
PubMedID
言語
英語
NII資源タイプ
学術雑誌論文
広大資料タイプ
学術雑誌論文
DCMIタイプ
text
フォーマット
application/pdf
著者版フラグ
publisher
権利情報
Copyright © 2017, Japanese Society of Allergology. Production and hosting by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
関連情報URL
部局名
医歯薬保健学研究科