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ID 20584
本文ファイル
著者
Tauchi, Shunsuke
Iwanaga, Koichiro
Mimura, Takeshi
Kitamura, Yoshitaka
Watanabe, Hirokazu
Adachi, Shuji
Sakuma, Toshiko
Ohbayashi, Chiho
キーワード
bronchioloalveolar carcinoma
sublobar resection
adenocarcinoma
FDG-PET/CT
NDC
医学
抄録(英)
Objective: The aggressiveness of small adenocarcinomas has not been fully evaluated using integrated positron emission tomography/computed tomography (PET/CT). We investigated malignant aggressiveness according to PET/CT, high-resolution computed tomography (HR-CT) findings and the proportions of pathologically defined bronchioloalveolar carcinomas (BACs) in cT1N0M0 lung adenocarcinoma. Methods: Sixty consecutive patients with cT1N0M0 lung adenocarcinomas of 3 cm or less in diameter, underwent fluorodeoxyglucose (FDG)-PET/CT and HR-CT followed by complete tumor resection. Correlations between the proportion of BAC and maximum standardized uptake value (SUV) on PET/CT, ground-glass opacity (GGO) and tumor shadow disappearance rate (TDR) were investigated and the findings were compared with clinicopathological features. Results: Lymphatic and vascular invasion occurred in 18 (30%) and 13 (22%) patients, respectively, whereas hilar or mediastinal lymph nodes were involved in 8 patients (13%). Maximum SUV generally seemed the most valuable predictor of lymphatic invasion, vascular invasion and nodal metastasis, compared with GGO, TDR and BAC ratios. Although the association was significant between the BAC ratio versus maximum SUV, GGO ratio and TDR (all p<0.0001), maximum SUV (R2 = 0.245) was less correlated with the BAC ratio than the GGO ratio (R2 = 0.554) and TDR (R2 = 0.671). Conclusions: The malignant behavior of small adenocarcinomas with a lower maximum SUV and a greater proportion of GGO, TDR and BAC was less aggressive. Maximum SUV was a more powerful clinical predictor of biological tumor performance, independently of pathological BAC proportion. Preoperative assessment of maximum SUV on PET/CT in addition to the GGO ratio and TDR on HR-CT might be useful to guide treatment strategies for small adenocarcinomas.
掲載誌名
The Journal of Thoracic and Cardiovascular Surgery
133巻
6号
開始ページ
1448
終了ページ
1454
出版年月日
2007
出版者
Mosby-Elsevier
ISSN
0022-5223
NCID
言語
英語
NII資源タイプ
学術雑誌論文
広大資料タイプ
学術雑誌論文
DCMIタイプ
text
フォーマット
application/pdf
著者版フラグ
author
権利情報
Copyright (c) 2007 The American Association for Thoracic Surgery.
部局名
原爆放射線医科学研究所