Titanium Immobilized with an Antimicrobial Peptide Derived from Histatin Accelerates the Differentiation of Osteoblastic Cell Line, MC3T3-E1
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ID | 30399 |
本文ファイル | |
著者 |
Makihira, Seicho
Shuto, Takahiro
Okamoto, Keishi
Mine, Yuichi
Takamoto, Yuko
Tsuji, Koichiro
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キーワード | antimicrobial peptide
titanium surface
MC3T3-E1 cells
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NDC |
医学
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抄録(英) | The objective of this study was to evaluate the effect of titanium immobilized with a cationic antimicrobial peptide (JH8194) derived from histatin on the biofilm formation of Porphyromonas gingivalis and differentiation of osteoblastic cells (MC3T3-E1). The titanium specimens (Ti) were immobilized with JH8194, according to the method previously described. The colonization of P. gingivalis on JH8194-Ti was significantly lower than that on control- and blocking-Ti. JH8194-Ti enhanced the mRNA expressions of Runx2 and OPN, and ALPase activity in the MC3T3-E1, as compared with those of control- and blocking-Ti. These results, taken together, suggested the possibility that JH8194-Ti may be a potential aid to shorten the period of acquiring osseointegration.
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掲載誌名 |
International Journal of Molecular Sciences
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巻 | 11巻
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号 | 4号
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開始ページ | 1458
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終了ページ | 1470
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出版年月日 | 2010-04-02
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出版者 | Molecular Diversity Preservation International-MDPI
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ISSN | 1422-0067
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NCID | |
出版者DOI | |
言語 |
英語
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NII資源タイプ |
学術雑誌論文
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広大資料タイプ |
学術雑誌論文
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DCMIタイプ | text
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フォーマット | application/pdf
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著者版フラグ | publisher
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権利情報 | Copyright (c) 2010 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland.
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関連情報URL | |
部局名 |
医歯薬学総合研究科
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