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ID 20327
本文ファイル
著者
Jin, Chen
Makihira, Seicho
Hamada, Taizo
Samaranayake Lakshman P.
抄録(英)
Statement of problem. There is a possibility that the colonization of oral surfaces, including the denture fitting surface, can serve as a reservoir for disseminated Candidal infections, particularly in immuno-compromised hosts, such as AIDS patients. Histatins are a group of small, cationic antifungal peptides present in human saliva. Several recent reports have suggested the therapeutic potential of this peptides in patients with oral candidosis. However, little information is available on the antifungal activity of the peptides agaist Candida albicans isolates from HIV positive patients. Purpose. Fungicidal effects of Histatin-5 against oral isolates of Candida albicans from HIVpositive and -negative patients were examined. Methods/Materials. Two isolates of C. albicans from HIV-positive patients (two males), three isolates from HIV-negative patients (two males amd one female healthy donors) and one ATCC strain were used. Fungicidal assays were performed on exponential C. albicans cells in the presence or absence of Histatin-5 (0.315-50 mM). Results. Fifty mMHistatin-5 killed more than 950f C. albicans isolates from HIV-negative patients and killed more than 9027777751240f ATCC strain. In contrast, Histatin-5 induced 75.3-0x1.4b3a0b6a4aap-149nd 66.11024570420ss of viability of two C. albicans isolates from HIV-positive patients, respectively, which were statistically less effective than the fungicidal effects against any isolates from HIV negative patients, or a reference strain (ANOVA; p<0.05). Conclusion. C. albicans isolates from oral cavity of HIV-positive patients were less sensitive to Histatin-5, as compared with the oral isolates from HIV-negative patients. Clinical Implications Although our results demonstrated the therapeutic potential of Histatin- 5 against oral candidosis, we pointed out that the antifungal effects of the peptide against isolates of C. albicans from HIV-positive patients were relatively low. Thus the improvement of efficacy of the peptides should be required.
掲載誌名
The Journal of Prosthetic Dentistry
88巻
3号
開始ページ
263
終了ページ
267
出版年月日
2002-09
出版者
Elsevier
ISSN
0022-3913
NCID
出版者DOI
PubMedID
言語
英語
NII資源タイプ
学術雑誌論文
広大資料タイプ
学術雑誌論文
DCMIタイプ
text
フォーマット
application/pdf
著者版フラグ
author
権利情報
Copyright (c) 2002 Elsevier Science B.V.
関連情報URL
部局名
医歯薬学総合研究科