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ID 46717
本文ファイル
著者
Matsumoto, Kazuaki
Kanazawa, Naoko
Shigemi, Akari
Ikawa, Kazuro 大学院医歯薬保健学研究科(薬) 広大研究者総覧
Morikawa, Norifumi 大学院医歯薬保健学研究科(薬) 広大研究者総覧
Koriyama, Toyoyasu
Orita, Michiyo
Kawamura, Hideki
Tokuda, Koichi
Nishi, Junichiro
Takeda, Yasuo
キーワード
Clostridium difficile
antiinfective agent
gastric acid-suppressive agent
anticancer agent
steroid
recurrence
NDC
医学
抄録(英)
The antimicrobial agents vancomycin and metronidazole have been used to treat Clostridium difficile infections (CDIs). However, it remains unclear why patients are at risk of treatment failure and recurrence. Therefore, this study retrospectively examined 98 patients with CDIs who were diagnosed based on the detection of toxin-positive C. difficile to determine the risk factors affecting drug treatment responses and the recurrence of CDI. No significant difference was observed in the cure rate or dosage between the vancomycin and metronidazole groups. The 90-d mortality rate and total number of drugs associated with CDIs, including antiinfective agents used within 2 months before the detection of toxin-positive C. difficile, were significantly lower in the treatment success group than in the failure group. The total number of antiinfective agents and gastric acid-suppressive agents used during CDI therapy was also significantly lower in the success group than in the failure group. The period from the completion of CDI therapy to restarting the administration of anticancer agents and steroids was significantly longer in patients without than in patients with recurrence. These results indicate that the total number of drugs associated with CDIs should be minimized to reduce the risk of CDIs, that not only antibiotics but also gastric acid-suppressive agents should be discontinued during CDI therapy to increase therapeutic efficacy, and that the use of anticancer agents and steroids should be delayed as long as possible after patients are cured by CDI therapy to prevent recurrence.
掲載誌名
Biological and Pharmaceutical Bulletin
37巻
11号
開始ページ
1811
終了ページ
1815
出版年月日
2014-11-01
出版者
The Pharmaceutical Society of Japan
ISSN
0918-6158
1347-5215
NCID
出版者DOI
NAID
言語
英語
NII資源タイプ
学術雑誌論文
広大資料タイプ
学術雑誌論文
DCMIタイプ
text
フォーマット
application/pdf
著者版フラグ
publisher
権利情報
Copyright (c) 2014 The Pharmaceutical Society of Japan
関連情報URL
部局名
医歯薬保健学研究科