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ID 28880
本文ファイル
著者
Matsuura, Kanji
Kashiwado, Kozo
Fujita, Kazushi
Akagi, Yukio
Yuki, Shintarou
Murakami, Yuji
Wadasaki, Koichi
Monzen, Yoshio
Ito, Atsushi
Kagemoto, Masayuki
Mori, Masaki
Ito, Katsuhide
キーワード
Involved-field radiation therapy (IFRT)
Elective nodal irradiation (ENI)
Three-dimensional conformal radiation therapy (3DCRT)
Non-small-cell lung cancer (NSCLC)
Carboplatin (CBDCA)
Paclitaxel (PTX)
NDC
医学
抄録(英)
We aimed to evaluate the feasibility and efficacy of hypofractionated involved-field radiation therapy (IFRT) omitting elective nodal irradiation (ENI) with concurrent chemotherapy for locally advanced non-small-cell lung cancer (NSCLC). Between July 2004 and July 2006, ten patients with locally advanced NSCLC were included in this study. One had stage IIIA and 9 had stage IIIB disease. The treatment consisted of IFRT in fractions of 2.5 Gy and weekly carboplatin (CBDCA)/paclitaxel (PTX). Hypofractionated IFRT with a median total dose of 65 Gy with median percent total lung volume exceeding 20 Gy (V20) of 20.2%, and a median of five courses of chemotherapy with weekly CBDCA (area under the curve, 1.5-2.0)/PTX (30-35 mg/m(2)) were given to all patients. The median survival time and the 1-, 2-, and 3-year overall survival rates were 29.5 months and 90.0%, 58.3%, and 43.8%, respectively. No elective nodal failure was encountered during the median follow up of 18.2 months. No acute or late toxicities of grade 3 or worse were observed. No in-field recurrence occurred in the group with a total dose of 67.5 Gy or more, but there was such recurrence in 83.3% of those in the group with less than 67.5 Gy. Hypofractionated IFRT with weekly CBDCA/PTX was a feasible treatment regimen. Hypofractionated IFRT with a total dose of 67.5 Gy or more could be a promising modality to improve the treatment results in patients with locally advanced NSCLC.
掲載誌名
International Journal of Clinical Oncology
14巻
5号
開始ページ
408
終了ページ
415
出版年月日
2009-10-24
出版者
Springer Tokyo
ISSN
1341-9625
NCID
出版者DOI
言語
英語
NII資源タイプ
学術雑誌論文
広大資料タイプ
学術雑誌論文
DCMIタイプ
text
フォーマット
application/pdf
著者版フラグ
author
権利情報
Copyright (c) 2009 Springer
関連情報
The original publication is available at www.springerlink.com
関連情報URL
部局名
医歯薬学総合研究科