Formation of lipid membrane‐incorporated small π‐molecules bearing hydrophilic groups
この文献の参照には次のURLをご利用ください : https://ir.lib.hiroshima-u.ac.jp/00046324
ID | 46324 |
本文ファイル | |
著者 |
Ashizawa, Kengo
Tsuchiya, Yuki
Ueda, Masafumi
大学院工学研究院
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NDC |
化学
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抄録(英) | Nineteen poorly water‐soluble π‐conjugated molecules were evaluated in terms of their ability to be stably incorporated into lipid membranes. The resulting lipid membrane-incorporated π‐conjugated guest molecules (LMIGs) were classified into four categories, including (i) those that formed stable LMIGs; (ii) those where some of guest molecules precipitated; (iii) those that formed small self‐aggregates consisting of lipids and/or guest molecules; and (iv) those that leaked some of the guest molecules into the bulk water. Compounds belonging to category (ii) were confirmed by UV‐vis absorption analysis. In contrast, compounds belonging to categories (i), (iii) and (iv) were discriminated based on their 1H NMR spectra and the broadening or disappearance of the peaks of the guest molecules and the lipids in LMIGs and large liposomes. Several LMIGs could be converted from one category to another using other lipids. Furthermore, the guest molecules belonging to category (iv) were successfully predicted using the octanol‐water partition coefficient, which was calculated by simulation.
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内容記述 | This work was supported by the Japanese Society for the Promotion of Science (JSPS) KAKENHI Grant‐in‐Aid for Scientific Research (B) (Grant No. JP16H04133) and a Grant‐in‐Aid for Challenging Exploratory Research (Grant No. JP16K13982).
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掲載誌名 |
RSC Advances
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巻 | 6巻
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号 | 82号
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開始ページ | 78505
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終了ページ | 78513
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出版年月日 | 2016-08-12
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出版者 | Royal Society of Chemistry
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ISSN | 2046-2069
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出版者DOI | |
言語 |
英語
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NII資源タイプ |
学術雑誌論文
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広大資料タイプ |
学術雑誌論文
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DCMIタイプ | text
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フォーマット | application/pdf
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著者版フラグ | author
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権利情報 | This journal is © The Royal Society of Chemistry 2016
This is the accepted manuscript of an article is available at http://dx.doi.org/10.1039/C6RA18635A.
This is not the published version. Please cite only the published version. この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。
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部局名 |
工学研究科
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