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ID 38117
本文ファイル
著者
Ito, Hisao
Oda, Noriko
Kameda, Takashi
Nakayama, Hirofumi
Tahara, Eiichi
キーワード
Hwnan stomach cancer
TMK-1 cell
Cytogenetics
Flow cytometly
NDC
医学
抄録(英)
We examined a human gastric carcinoma cell line TMK-1 cytogenetically by G-banding technique. TMK-1 cells were characterized not only by numerical aberrations but also by structural rearrangements affecting various chromosomes. The modal chromosome number was found to be in the hypotriploid range with most ranging between 64 and 66. Flow cytometry revealed near triploid DNA histogram which was correlated well with chromosome counts. Gain of chromosome 7, 9, 11, and X was found in all of the 25 cells examined and trisomy of chromosome 3, 5, 10, 19, 21 and 22 was also frequently detected. Loss of Y chromosome was shown in all of the cells and monosomy of chromosome 6 and 13 was frequently detected. The most conspicuous rearrangements involved chromosome 6, 12, and 16 which showed complex nonreciprocal translocation. Twenty-two cells (88%) had isochromosome of 12q. A brief review is made of reported karyotype of human gastric cancers.
内容記述
This study was supported in part by Grant-in-Aid for Cancer Research from the Ministry of Health and Welfare, Tokyo and Tsuchiya Medical Foundation, Hiroshima, Japan.
掲載誌名
Hiroshima Journal of Medical Sciences
38巻
3号
開始ページ
121
終了ページ
124
出版年月日
1989-09
出版者
Hiroshima University Medical Press
ISSN
0018-2052
NCID
PubMedID
言語
英語
NII資源タイプ
紀要論文
広大資料タイプ
学内刊行物(紀要等)
DCMIタイプ
text
フォーマット
application/pdf
著者版フラグ
publisher
部局名
医歯薬学総合研究科
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