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ID 17065
本文ファイル
著者
Hyoda, Kanae
Okuma, Yasunobu
Nomura, Yasuyuki
キーワード
4-(2-aminoethyl)-benzenesulfonyl fluoride (AEBSF)
phosphatidylinositol 3-kinase (PI3K)
CHOP
endoplasmic reticulum stress
NDC
医学
抄録(英)
Endoplasmic reticulum stress contributes to several diseases such as neurodegenerative disorders and diabetes. In the previous report, we found that phosphatidylinositol 3-kinase (PI3K) down-regulation is important for inducing CHOP expression, an endoplasmic reticulum stress-induced transcription factor. In the present study, we investigated the effect of 4-(2-aminoethyl)-benzenesulfonyl fluoride (AEBSF), a serine protease inhibitor, on PI3K inhibitor-induced CHOP expression. We found that AEBSF completely inhibited PI3K inhibitor-induced CHOP expression at both mRNA and protein levels. It is suggested that AEBSF is an important drug from a pharmacological point of view and the results may have important implications for understanding endoplasmic reticulum stress-related diseases.
掲載誌名
European Journal of Pharmacology
554巻
1号
開始ページ
8
終了ページ
11
出版年月日
2007-01-05
出版者
Elsevier
ISSN
0014-2999
NCID
出版者DOI
PubMedID
言語
英語
NII資源タイプ
学術雑誌論文
広大資料タイプ
学術雑誌論文
DCMIタイプ
text
フォーマット
application/pdf
著者版フラグ
author
権利情報
Copyright (c) 2007 Elsevier Ltd.
関連情報URL(IsVersionOf)
http://dx.doi.org/10.1016/j.ejphar.2006.09.063
部局名
医歯薬学総合研究科