We tried to apply a personal computer especially word processor and E-mail system for an adolescent with visual, physical and speech handicaps, and we guided him how to operate them by himself through the interface called Ke:nx. We taught him and his parents how to apply word processor and E-mail system designing Ke:nx program and connecting his machine to computer network. By trial and error, he could handle his machine and enjoy his life by using E-mail finally. But, he still needed his parent's support. So we need further improvement of the program of Ke:nx for him in order to operate his machine by himself. Taking into consideration of various needs of people with multiple handicaps, we have to develop personal computer system and support system for all user of E-mail.