このエントリーをはてなブックマークに追加
ID 26005
本文ファイル
別タイトル
RELATIONSHIP BETWEEN OXIDATION OF MYOFIBRILLAR PROTEINS AND CONTRACTILE PROPERTIES IN SOLEUS MUSCLES FROM HYPERTHYROID RAT
著者
山田 崇史
三島 隆章
坂本 誠
杉山 美奈子
松永 智
キーワード
reactive oxygen species
hyperthyroidism
specific force reduction
redox status
NDC
医学
抄録(英)
We tested the hypothesis that a force reduction in soleus muscles from hyperthyroid rats would be associated with oxidative modification of myofibrillar proteins. Daily injection of thyroid hormone [3,5,3'-triiodo-L-thyronine (T_3)] for 21 days depressed isometric forces in whole soleus muscle across a range of stimulus frequencies (1, 10, 20, 40, 75 and 100Hz) (P<0.05). In fiber bundles, hyperthyroidism also led to pronounced reductions (P<0.05) in both K^+- and 4-chloro-m-cresol-induced contracture forces. The degrees of the reductions were similar between these two contractures. These reductions in force production were accompanied by a remarkable increment (103% ; P<0.05) in carbonyl groups comprised in myofibrillar proteins. In additional experiments, we have also tested the efficacy of carvedilol, a non-selective β_1-β_2-blocker that possesses anti-oxidative properties. Treatment with carvedilol prevented T_3-induced oxidation of myofibrillar proteins. However, carvedilol did not improve the hyperthyroid-induced reductions in force production. These data suggest that oxidative modification of myofibrillar proteins may not account for the reductions in force production of hyperthyroid rat soleus muscle.
掲載誌名
体力科学 : Japanese Journal of Physical Fitness and Sports Medicine
56巻
5号
開始ページ
473
終了ページ
480
出版年月日
2007-10-01
出版者
日本体力医学会
ISSN
0039-906X
NCID
言語
日本語
NII資源タイプ
学術雑誌論文
広大資料タイプ
学術雑誌論文
DCMIタイプ
text
フォーマット
application/pdf
著者版フラグ
publisher
権利情報
日本体力医学会
本文データは学協会の許諾に基づきCiNiiから複製したものである
関連情報URL
部局名
総合科学研究科