Reg IV is a serum biomarker for gastric cancer patients and predicts response to 5-fluorouracil-based chemotherapy
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ID | 20727 |
本文ファイル | |
著者 |
Mitani, Yoshitsugu
Matsumura, Shunji
Yoshida, Kazuhiro
Noguchi, Tsuyoshi
Ito, Masanori
Kuniyasu, Hiroki
Kamata, Nobuyuki
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キーワード | Reg IV
apoptosis
5-fluorouracil
serum tumor marker
SAGE
gastric cancer
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NDC |
医学
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抄録(英) | Regenerating gene family, member 4 (Reg IV), a secreted protein, is overexpressed in several cancers, including gastric cancer (GC). In the present study, we measured Reg IV levels in sera from patients with GC by enzyme-linked immunosorbent assay. We also examined the effect of forced Reg IV expression on the apoptotic susceptibility to 5-fluorouracil (5-FU). Forced expression of Reg IV inhibited 5-FU-induced apoptosis. Induction of Bcl-2 and dihydropyrimidine dehydrogenase was involved in inhibition of apoptosis. Among 36 GC patients treated with a combination chemotherapy of low-dose 5-FU and cisplatin, all 14 Reg IV-positive patients showed no change or disease progression. The serum Reg IV concentration was similar between healthy individuals (mean±s.e., 0.52±0.05 ng/ml) and patients with chronic-active gastritis (0.36±0.09 ng/ml). However, the serum Reg IV concentration in presurgical GC patients was significantly elevated (1.96±0.17 ng/ml), even at stage I. The diagnostic sensitivity of serum Reg IV (36.1%) was superior to that of serum carcinoembryonic antigen (11.5%) or carbohydrate antigen 19-9 (13.1%). These results indicate that expression of Reg IV is a marker for prediction of resistance to 5-FU-based chemotherapy in patients with GC. Serum Reg IV represents a novel biomarker for GC.
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掲載誌名 |
Oncogene
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巻 | 26巻
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号 | 30号
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開始ページ | 4383
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終了ページ | 4393
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出版年月日 | 2007
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出版者 | Nature Publishing Group
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ISSN | 0950-9232
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NCID | |
出版者DOI | |
PubMedID | |
言語 |
英語
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NII資源タイプ |
学術雑誌論文
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広大資料タイプ |
学術雑誌論文
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DCMIタイプ | text
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フォーマット | application/pdf
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著者版フラグ | author
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権利情報 | Copyright (c) 2007 Nature Publishing Group.
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関連情報URL | |
部局名 |
医歯薬学総合研究科
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