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ID 48188
本文ファイル
著者
Tsushima, Tadahiro
Matsubara, Kiminori 大学院教育学研究科 広大研究者総覧
Ohkubo, Takeshi
Inoue, Yoshikazu
Takahashi, Koretaro
キーワード
angiogenesis
phospholipids
lysophospholipids
omega 3
抄録(英)
Suppression of leukemia, colon cancer, myeloma, and fibrosarcoma to some extent by omega 3 fatty acid bound phospholipids has been reported in the last two decade. However, the anti-angiogenic activity of those phospholipids is still not known. Four kinds of marine phospholipid molecular species i.e. starfish EPA bound diacyl phospholipid (EPA-PC), EPA bound monoacyl phospholipid (EPA-LPC) which was prepare via Lipozyme RMIM mediated partial hydrolysis of EPA-PC, squid DHA bound diacyl phospholipid (DHA-PC), and DHA bound monoacyl phospholipid (DHA-LPC) which was also prepare via Lipozyme RMIM mediated partial hydrolysis of DHA-PC, were subjected to antiangiogenic activity assay by using a piece of rat main artery and a human umbilical cord vein endothelial cell. The lengths of micro vein generated from those tissues after incubation with the above four kinds of phospholipid molecular species were measured and compared. EPA-LPC and DHA-LPC showed strong antiangiogenic activity on the rat main artery tissue, while on the human umbilical cord vein endothelial cells, 100 μM of EPA-LPC in the culture medium, exhibited the most effective suppression on angiogenesis, followed by 100 μM of DHA-LPC. It was concluded that EPA-LPC obtained via Lipozyme RMIM mediated partial hydrolysis of EPA-PC is the most effective omega 3 phospholipid on anti-angiogenesis.
掲載誌名
Journal of Oleo Science
61巻
8号
開始ページ
427
終了ページ
432
出版年月日
2012
出版者
公益社団法人 日本油化学会
ISSN
1345-8957
1347-3352
NCID
出版者DOI
言語
英語
NII資源タイプ
学術雑誌論文
広大資料タイプ
学術雑誌論文
DCMIタイプ
text
フォーマット
application/pdf
著者版フラグ
publisher
権利情報
Copyright (c) 2012 by Japan Oil Chemists' Society
関連情報URL
部局名
教育学研究科