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ID 25589
本文ファイル
著者
Shiraishi, Jun-ichi
Yanagita, Kouichi
Fujita, Masanori
キーワード
POMC
food intake
insulin
central nervous system
chick
melanocortins
NDC
動物学
抄録(英)
Growing evidence suggests that insulin interacts with both orexigenic and anorexigenic peptides in the brain for the control of feeding behavior in mammals. However, the action of central insulin in chicks has not yet been identified. In the present study, we investigated the effects of central injection of insulin on feeding behavior in chicks. Intracerebroventricular (ICV) administration of insulin, at doses that do not influence peripheral glucose levels, significantly inhibited food intake in chicks. Central injection of insulin in chicks significantly increased expression of pro-opiomelanocortin (POMC) mRNA, and decreased that of neuropeptide Y (NPY) mRNA. Finally, co-injection of the melanocortin antagonist (SHU9119 or HS014) prevented the reduction in food intake caused by ICV administration of insulin. These data suggest that insulin functions in chicks as an appetite-suppressive peptide in the central nervous system, and that the central melanocortin system mediates this anorexic effect of insulin, as in mammals.
掲載誌名
Domestic Animal Endocrinology
34巻
3号
開始ページ
227
終了ページ
229
出版年月日
2008-04
出版者
Elsevier Inc
ISSN
0739-7240
NCID
出版者DOI
言語
英語
NII資源タイプ
学術雑誌論文
広大資料タイプ
学術雑誌論文
DCMIタイプ
text
フォーマット
application/pdf
著者版フラグ
author
権利情報
Copyright (c) 2007 Elsevier Inc
関連情報URL(IsVersionOf)
http://dx.doi.org/10.1016/j.domaniend.2007.05.002
部局名
生物圏科学研究科