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ID 25588
本文ファイル
著者
Shiraishi, Jun-ichi
Yanagita, Kouichi
Fujita, Masanori
キーワード
β-Endorphin
food intake
insulin
central nervous system
neonatal chick
melanocortin system
NDC
動物学
抄録(英)
Pro-opiomelanocortin (POMC) neurons in the hypothalamus are direct targets of peripheral satiety signals, such as leptin and insulin in mammals. The stimulation of these signals activates hypothalamic POMC neurons and elevates POMC-derived melanocortin peptides that inhibit food intake in mammals. On the other hand, it has been recognized that β-endorphin, a post-translational processing of POMC, acts in an autoreceptor manner to the μ-opioid receptor (MOR) on POMC neurons, diminishing POMC neuronal activity in mammals. Recently, we found that central insulin functions as an anorexic peptide in chicks. Thus, the present study was done to elucidate whether β-endorphin affects the activation of POMC neurons by insulin in neonatal chicks. Consequently, quantitative real-time PCR analysis shows that intracerebroventricular (ICV) injection of insulin with β-endorphin significantly decreases brain POMC mRNA expression when compared with insulin alone. In addition, co-injection of MOR agonist (β-endorphin or [d-Ala2, N-MePhe4, Gly5-ol]-enkephalin (DAMGO)) significantly attenuates insulin-induced hypophagia in chicks. These data suggest that β-endorphin regulates the activity of the central melanocortin system, and its activation may provide an inhibitory feedback mechanism in the brain of neonatal chicks.
掲載誌名
Neuroscience Letters
439巻
3号
開始ページ
227
終了ページ
229
出版年月日
2008-07
出版者
Elsevier Ireland Ltd
ISSN
0304-3940
NCID
出版者DOI
言語
英語
NII資源タイプ
学術雑誌論文
広大資料タイプ
学術雑誌論文
DCMIタイプ
text
フォーマット
application/pdf
著者版フラグ
author
権利情報
Copyright (c) 2008 Elsevier Ireland Ltd
関連情報URL(IsVersionOf)
http://dx.doi.org/10.1016/j.neulet.2008.05.040
部局名
生物圏科学研究科