Effects of N-terminal fragments of β-endorphin on feeding in chicks
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central nervous system
It is known that N-terminal fragments of β-endorphin have biological activities, such as an antagonism effect of β-endorphin (1–31) on the secretion of hormones or thermoregulation in mammals. We studied the effects of the N-terminal fragments on feeding behavior in male broiler chicks. Intracerebroventricular administration of β-endorphin (1–27) (0.4 nmol) stimulated feeding behavior compared with saline control during the 60-min experimental period. β-Endorphin (1–17) (2.0 nmol) also increased food intake at 30 min postinjection. Co-injection of either β-endorphin (1–27) or (1–17) was effective in reducing full-length β-endorphin-induced feeding in chicks. These data suggest that the N-terminal fragments of β-endorphin act as a partial agonist, and may regulate the activity of the central opioidergic system in chicks.
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