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ID 27771
本文ファイル
著者
Tamaki, Masako
Matsuoka, Tatsuya
Hori, Tadao
キーワード
Sleep
Memory
Learning
Sleep spindle
Fast spindle
Premotor cortex
Parietal associative area
NDC
医学
抄録(英)
Objective: The present study examined whether slow and/or fast sleep spindles are related to visuomotor learning, by examining the densities of current sleep spindle activities. Methods: Participants completed a visuomotor task before and after sleep on the learning night. This task was not performed on the non-learning night. Standard polysomnographic recordings were made. After the amplitudes of slow and fast spindles were calculated, sLORETA was used to localize the source of slow and fast spindles and to investigate the relationship between spindle activity and motor learning. Results: Fast spindle amplitude was significantly larger on the learning than on the non-learning nights, particularly at the left frontal area. sLORETA revealed that fast spindle activities in the left frontal and left parietal areas were enhanced when a new visuomotor skill was learned. There were no significant learning-dependent changes in slow spindle activity. Conclusions: Fast spindle activity increases in cortical areas that are involved in learning a new visuomotor skill. The thalamocortical network that underlies the generation of fast spindles may contribute to the synaptic plasticity that occurs during sleep. Significance: Activity of fast sleep spindles is a possible biomarker of memory deficits.
掲載誌名
Clinical Neurophysiology
120巻
5号
開始ページ
878
終了ページ
886
出版年月日
2009
出版者
Elsevier Ireland Ltd
ISSN
1388-2457
NCID
出版者DOI
言語
英語
NII資源タイプ
学術雑誌論文
広大資料タイプ
学術雑誌論文
DCMIタイプ
text
フォーマット
application/pdf
著者版フラグ
author
権利情報
Copyright (c) 2009 International Federation of Clinical Neurophysiology Published by Elsevier Ireland Ltd.
関連情報URL
部局名
総合科学研究科